SPLICE: Sub-second diffusion-sensitive MR imaging using a modified fast spin-echo acquisition made
SPLICE: Sub-second diffusion-sensitive MR imaging using a modified fast spin-echo acquisition made
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DOI：
10.1002/mrm.1910380418
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发表时间：
1997-10-01
影响因子：
3.3
通讯作者：
Schick, F
中科院分区：
文献类型：
--
作者：
Schick, F
最近通过磁共振成像测量组织中表观扩散系数的人类研究是通过耗时的标准自旋回波采集序列和导航回波的相位校正进行的。扩散加权平面回波序列已被证明是脑成像的快速替代方法，这两种方法在胸部或腹部部位的应用中都显示出固有的缺点。这里报告了一种将单次扩散加权成像与改进的快速自旋回波采集模式相结合的新方法。这种修改是必要的，因为正常的快速自旋回波采集需要磁化和重聚焦脉冲之间的特定相位关系。不幸的是，在扩散敏感制备后不提供这种相位关系。因此，开发了分离回波采集模式，并且该模式对磁化相位不敏感。快速自旋回波采集和扩散加权的优点可以结合在 SPLICE 序列中（用于扩散成像的快速自旋回波信号的分割采集）。来自身体不同部位的一系列亚秒扩散加权图像显示了新技术的适用性。
Recent human studies for measuring of the apparent diffusion coefficient in tissue by magnetic resonance imaging have been conducted by time-consuming standard spin-echo acquisition sequences and phase correction with navigator echoes. Diffusion-weighted echo-planar sequences have been shown to be rapid alternatives for brain imaging, Both methods show inherent disadvantages in applications on thoracic or abdominal sites. A new approach combining single-shot diffusion-weighted imaging with a modified fast spin-echo acquisition mode is reported here. The modification is necessary, because normal fast spin-echo acquisition requires a particular phase relation between the magnetization and the refocusing pulses. Unfortunately, this phase relation is not provided after diffusion sensitive preparation. Therefore, the split echo acquisition mode was developed and is shown to be insensitive to the phase of the magnetization. The advantages of both fast spin-echo acquisition and diffusion weighting can be combined in the SPLICE sequence (split aqcuisition of fast spin-echo signals for diffusion imaging). The applicability of the new technique is shown by series of sub-second diffusion-weighted images from different parts of the body.