BrOnsted Acid-Mediated Hydrative Arylation of Unactivated Alkynes
BrOnsted Acid-Mediated Hydrative Arylation of Unactivated Alkynes
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DOI：
10.1002/chem.201600432
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发表时间：
2016-03-24
影响因子：
4.3
通讯作者：
Maulide, Nuno
中科院分区：
文献类型：
--
作者：
Kaiser, Daniel;Veiros, Luis F.;Maulide, Nuno
未活化的炔与芳基亚砜的布朗斯台德酸介导的反应导致同时水合和分子间C-C键的形成。这种无溶剂和无金属的转化以原子经济的方式直接提供-芳基化羰基化合物作为正式水合芳基化的产物。该产品带有有用的合成手柄，用于进一步功能化。
The BrOnsted acid-mediated reaction of unactivated alkynes with aryl sulfoxides leads to simultaneous hydration and intermolecular C-C bond formation. This solvent- and metal-free transformation directly delivers -arylated carbonyl compounds as the products of a formal hydrative arylation in an atom-economical manner. The products bear useful synthetic handles for further functionalization.