Interaction of noradrenaline and cortisol predicts negative intrusive memories in posttraumatic stress disorder
Interaction of noradrenaline and cortisol predicts negative intrusive memories in posttraumatic stress disorder
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DOI：
10.1016/j.nlm.2013.11.018
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发表时间：
2014-07-01
影响因子：
2.7
通讯作者：
Felmingham, Kim L.
中科院分区：
文献类型：
--
作者：
Nicholson, Emma L.;Bryant, Richard A.;Felmingham, Kim L.
最近的证据表明，在编码过程中去甲肾上腺素（NE）和皮质醇（CURT）的相互作用导致情感记忆的更大巩固。创伤后应激障碍（PTSD）的趋同模型表明，在PTSD中，CURT和NE的释放导致更大的侵入性记忆。本研究探讨了编码过程中NE和CURT对PTSD患者回忆和侵入性记忆的影响。58名参与者（18名PTSD参与者，20名创伤暴露对照组和20名非创伤暴露对照组）在（a）基线和（B）观察负面情绪刺激后提供了NE（由唾液α淀粉酶; sAA）和CURT的唾液样本。延迟记忆回忆和侵入性记忆的负，中性和积极的刺激后两天，这个初始测试会话记录。与对照组相比，PTSD组对负性刺激有更高的NE水平，并报告了更多的负性刺激的侵入性记忆。回归分析显示，在PTSD组中，CURT和NE的相互作用显著预测了负面侵入性记忆。与对照组相比，创伤暴露组报告了显着更大的回忆负面图像，但与PTSD组没有显着差异。与其他组相比，PTSD组在编码过程中报告了更高水平的负面图像抑制。我们的研究结果证实，NE和CURT的相互作用显着预测更大的负面侵入性记忆，但这是专门发生在PTSD组。这表明，应激激素和情绪记忆之间的关系需要一定程度的高度唤醒，才能在创伤后应激障碍中表现出来。(C)2013年由Elsevier Inc.出版
Recent evidence suggests that an interaction of noradrenaline (NE) and cortisol (CURT) during encoding leads to greater consolidation of emotional memories. Convergent models of posttraumatic stress disorder (PTSD) suggest the release of CURT and NE lead to greater intrusive memories in PTSD. This study examined the effect of NE and CURT during encoding on recall and intrusive memories in PTSD. Fifty-eight participants (18 participants with PTSD, 20 trauma-exposed controls, and 20 non-trauma exposed controls) provided saliva samples of NE (indexed by salivary alpha amylase; sAA) and CURT at (a) baseline and (b) after viewing negative emotional stimuli. Delayed memory recall and number of intrusive memories of negative, neutral and positive stimuli were recorded two days after this initial testing session. The PTSD group had greater NE levels to negative stimuli and reported greater numbers of intrusive memories of negative stimuli than controls. Regression analyses revealed that the interaction of CURT and NE significantly predicted negative intrusive memories in the PTSD group. The trauma-exposed group reported significantly greater recall of negative images compared to controls, but did not differ significantly from the PTSD group. The PTSD group reported greater levels of suppression of negative images during encoding compared to the other groups. Our results confirm that the interaction of NE and CURT significantly predicts greater negative intrusive memories, but this occurs specifically in the PTSD group. This suggests that a level of heightened arousal is required for the relationship between stress hormones and emotional memory to manifest in PTSD. (C) 2013 Published by Elsevier Inc.