Synthesis, Crystal Structure, and DNA-Binding Properties of a New Cd(II) Complex Involving 2-(2-1H-Imidazolyl)-1H-Imdazolium Ligand
Synthesis, Crystal Structure, and DNA-Binding Properties of a New Cd(II) Complex Involving 2-(2-1H-Imidazolyl)-1H-Imdazolium Ligand
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DOI：
10.1002/cjoc.201090143
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发表时间：
2010-05-01
影响因子：
5.4
通讯作者：
Yang Pin
中科院分区：
文献类型：
--
作者：
Li Yanping;Yang Pin
合成了一种新的Cd（II）配合物Cd（H（3）biim）（2）（NCS）（2）Cl-2 [H（3）biim=2-（2- 1H-咪唑基）-1H-咪唑]，通过元素分析、红外光谱和X射线单晶衍射对其进行了表征。在X射线晶体学结构中，镉（II）离子由两个2-（2- 1H-咪唑基）-1H-咪唑鎓的两个氮原子、两个硫氰酸根离子的两个氮原子和两个Cl-配位。通过电子吸收光谱、荧光光谱、粘度测定、循环伏安和凝胶电泳等方法研究了配合物与小牛胸腺DNA的相互作用。这些结果表明，镉（II）配合物可以静电结合到DNA骨架的磷酸基团。有趣的是，我们发现该复合物可以在pH=7.2和37 ℃下切割pBR 322 DNA。
A new Cd(II) complex of Cd(H(3)biim)(2)(NCS)(2)Cl-2 [H(3)biim=2-(2-1H-imidazolyl)-1H-imidazolium] was synthesized and characterized by elemental analyses, FT-IR and X-ray single crystal diffraction. In the X-ray crystallography structure, the cadmium(II) ion is coordinated by two nitrogen atoms of two 2-(2-1H-imidazolyl)-1H-imdazolium, two nitrogen atoms of two thiocyanate ions and two Cl-. The interaction of the complex with calf thymus DNA was investigated through electronic absorption spectroscopy, fluorescence spectroscopy, viscosity measurement, cyclic voltammetry and gel electrophoresis. These results show that the Cd(II) complex can electrostatically bind to the phosphate group of DNA backbone. Interestingly, we found that the complex can cleave the pBR322 DNA at pH=7.2 and 37 degrees C.