The orientation of cell divisions determines the shape of Drosophila organs
The orientation of cell divisions determines the shape of Drosophila organs
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DOI：
10.1016/j.cub.2005.07.062
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发表时间：
2005-09-20
期刊：
影响因子：
9.2
通讯作者：
García-Bellido, A
中科院分区：
文献类型：
--
作者：
Baena-López, LA;Baonza, A;García-Bellido, A
器官的形状取决于发育过程中细胞增殖和细胞空间排列之间的协调[1-3]。关于调节细胞增殖的机制已经知道很多，但是细胞有序分布的过程仍然未知。这可以通过细胞的随机分裂来实现，这些细胞后来局部迁移到新的位置（细胞分配）[4]或通过极化细胞分裂（定向细胞分裂; OCD）。最近的数据表明，强迫症参与了一些形态发生过程，如脊椎动物原肠胚形成[5]，神经管关闭[6]和植物茎尖的生长[7];然而，对强迫症在器官发生过程中的贡献知之甚少。我们分析了果蝇野生型和突变型成虫盘发育过程中细胞分裂的方向模式。我们的研究结果表明，在成虫盘和相应器官的成人形态的细胞分裂的方向之间的因果关系，表明在器官形状定义的关键作用的强迫症。此外，我们发现，一个子集的平面细胞极性基因是必需的适当方向的细胞分裂在器官发育过程中。
Organ shape depends on the coordination between cell proliferation and the spatial arrangement of cells during development [1-3]. Much is known about the mechanisms that regulate cell proliferation, but the processes by which the cells are orderly distributed remain unknown. This can be accomplished either by random division of cells that later migrate locally to new positions (cell allocation) [4] or through polarized cell division (oriented cell division; OCD). Recent data suggest that the OCD is involved in some morphogenetic processes such as vertebrate gastrulation [5], neural tube closure [6], and growth of shoot apex in plants [7]; however, little is known about the contribution of OCD during organogenesis. We have analyzed the orientation patterns of cell division throughout the development of wild-type and mutant imaginal discs of Drosophila. Our results show a causal relationship between the orientation of cell divisions in the imaginal disc and the adult morphology of the corresponding organs, indicating a key role of OCD in organ-shape definition. In addition, we find that a subset of planar cell polarity genes is required for the proper orientation of cell division during organ development.