Nuclear Lipids in the Nervous System: What they do in Health and Disease
Nuclear Lipids in the Nervous System: What they do in Health and Disease
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DOI：
10.1007/s11064-016-2085-8
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发表时间：
2017-02-01
影响因子：
4.4
通讯作者：
Albi, Elisabetta
中科院分区：
文献类型：
--
作者：
Garcia-Gil, Mercedes;Albi, Elisabetta
在过去的20年里，人们广泛地证实细胞核中含有中性和极性的脂质，这些脂质分布在核膜、核仁、核基质和染色质中。核脂质可以显示形成核脂质微区的特定组织，并且具有结构和功能作用。根据它们的定位，核脂质发挥不同的作用，例如调节核膜和核基质流动性，但它们也可以作为维生素和激素功能的平台，用于活性染色质锚定，以及用于调节基因表达，DNA复制和转录。不同种类的脂质信号通路之间的串扰影响许多细胞类型的生理病理学。在神经细胞中，核脂质参与细胞增殖、分化、炎症、迁移和凋亡。核脂质代谢异常可能与肿瘤发生和神经退行性疾病如阿尔茨海默病和帕金森病等密切相关。
In the last 20 years it has been widely demonstrated that cell nucleus contains neutral and polar lipids localized in nuclear membranes, nucleoli, nuclear matrix and chromatin. Nuclear lipids may show specific organization forming nuclear lipid microdomains and have both structural and functional roles. Depending on their localization, nuclear lipids play different roles such as the regulation of nuclear membrane and nuclear matrix fluidity but they also can act as platforms for vitamin and hormone function, for active chromatin anchoring, and for the regulation of gene expression, DNA duplication and transcription. Crosstalk among different kinds of lipid signalling pathways influence the physiopathology of numerous cell types. In neural cells the nuclear lipids are involved in cell proliferation, differentiation, inflammation, migration and apoptosis. Abnormal metabolism of nuclear lipids might be closely associated with tumorigenesis and neurodegenerative diseases such as Alzheimer disease and Parkinson disease among others.