Epigenetics in liver disease: from biology to therapeutics.
Epigenetics in liver disease: from biology to therapeutics.
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DOI：
10.1136/gutjnl-2015-311292
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发表时间：
2016-11
期刊：
影响因子：
24.5
通讯作者：
Mann DA
中科院分区：
文献类型：
--
作者：
Hardy T;Mann DA
关于基因表达和细胞表型的基本表观遗传机制的知识已经足够先进，现在正在出现对慢性肝病表观遗传控制的新见解。肝病学家正在阐明DNA甲基化、组蛋白/染色质修饰和非编码RNA在特定肝脏病理中所起的作用。除了这些发现，直接从患者组织或体液中检测和定量表观遗传生物标志物的技术也取得了进展。本综述的前提是调查肝脏表观遗传学领域的最新进展，并探索其潜在的翻译由工业和临床肝病学家设计的新的治疗和诊断/预后生物标志物。特别是，我们在肝细胞癌，纤维化和非酒精性脂肪肝疾病的背景下提出了研究结果，这些疾病迫切需要新的临床干预措施和生物标志物。
Knowledge of the fundamental epigenetic mechanisms governing gene expression and cellular phenotype are sufficiently advanced that novel insights into the epigenetic control of chronic liver disease are now emerging. Hepatologists are in the process of shedding light on the roles played by DNA methylation, histone/chromatin modifications and non-coding RNAs in specific liver pathologies. Alongside these discoveries are advances in the technologies for the detection and quantification of epigenetic biomarkers, either directly from patient tissue or from body fluids. The premise for this review is to survey the recent advances in the field of liver epigenetics and to explore their potential for translation by industry and clinical hepatologists for the design of novel therapeutics and diagnostic/prognostic biomarkers. In particular, we present findings in the context of hepatocellular carcinoma, fibrosis and non-alcoholic fatty liver disease, where there is urgent unmet need for new clinical interventions and biomarkers.
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影响因子：
64.5
作者：
Carone BR;Fauquier L;Habib N;Shea JM;Hart CE;Li R;Bock C;Li C;Gu H;Zamore PD;Meissner A;Weng Z;Hofmann HA;Friedman N;Rando OJ
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29.4
作者：
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通讯作者：
Bendtsen F