Hippocampal glutamate concentration predicts cerebral theta oscillations during cognitive processing
Hippocampal glutamate concentration predicts cerebral theta oscillations during cognitive processing
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DOI：
10.1007/s00213-006-0397-0
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发表时间：
2006-07-01
影响因子：
3.4
通讯作者：
Heinz, A.
中科院分区：
文献类型：
--
作者：
Gallinat, J.;Kunz, D.;Heinz, A.
理由：脑电波反映了神经元的集体行为，并提供了对分布式网络处理的深入了解。额叶和海马θ振荡（4-7 Hz）与认知任务相关，动物研究表明谷氨酸能神经传递参与额叶-海马整合处理。这种关系缺乏人类证据。方法：在这里，我们研究了通过 3-T 质子磁共振波谱 (1H-MRS) 测量的海马区谷氨酸浓度与听觉目标检测范例期间脑电图 θ 活动之间的关联。结果：在刺激处理过程中，海马谷氨酸和额叶 theta 活动之间存在牢固的关系。此外，额叶θ振荡与反应速度有关。结论：结果表明，在刺激处理过程中，额叶皮层和海马区之间存在功能耦合，并支持海马体作为谷氨酸能神经传递驱动的神经节律发生器的观点。这些初步数据首次显示了体内测量的谷氨酸与人类基本大脑信息处理之间的关系。
Rationale: Brain waves reflect collective behavior of neurons and provide insight into distributed network processing. Frontal and hippocampal theta oscillations (4-7 Hz) were linked to cognitive tasks and animal studies have suggested an involvement of glutamatergic neurotransmission in integrative frontal-hippocampal processing. Human evidence for such relationships is lacking. Methods: Here, we studied the associations between glutamate concentrations in the hippocampal region, measured by a 3-T proton magnetic resonance spectroscopy (1H-MRS), and EEG theta activity during an auditory target detection paradigm. Results: A robust relationship between hippocampal glutamate and frontal theta activity during stimulus processing was found. Moreover, frontal theta oscillations were related to response speed. Conclusions: The results suggest a functional coupling between the frontal cortex and hippocampal region during stimulus processing and support the idea of the hippocampus as a neural rhythm generator driven by glutamatergic neurotransmission. These preliminary data show, for the first time, a relationship between in vivo measured glutamate and basic cerebral information processing in humans.