High mobility group box protein-1 (HMGB-1) as a new diagnostic marker in patients with acute appendicitis.
High mobility group box protein-1 (HMGB-1) as a new diagnostic marker in patients with acute appendicitis.
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DOI：
10.1186/1757-7241-19-27
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发表时间：
2011-04-20
期刊：
影响因子：
--
通讯作者：
Ozogul B
中科院分区：
文献类型：
--
作者：
Albayrak Y;Albayrak A;Celik M;Gelincik I;Demiryılmaz I;Yildirim R;Ozogul B
因此，本前瞻性研究的目的是评价术前血清高迁移率族蛋白-1（HMGB-1）水平对白色血细胞计数（WBC）正常的急性腹膜炎（AA）患者的诊断价值。我们的研究于2010年10月至2010年11月进行，包括20名健康对照组参与者和60名在土耳其Erzurum培训和研究医院急诊科就诊的急性腹痛患者，他们在剖腹手术后被病理诊断为AA，并同意参加研究。60例阑尾切除术患者中，男性36例，女性24例;健康组中，男性12例，女性8例。第1、2和3组患者的平均年龄分别为31.3 ± 15.4、34.0 ± 16.3和31.0 ± 13.1岁。第1、2和3组的WBC平均值分别为7.41 ± 2.02（x109/L）、15.71 ± 2.85（x109/L）和8.51 ± 1.84（x109/L）。第1组（健康人）、第2组（具有高WBC计数的AA患者）和第3组（具有正常WBC计数的AA患者）的HMGB-1水平分别为21.71 ± 11.36、37.28 ± 13.37和36.5 ± 17.73 ng/ml。AA患者血清HMGB-1水平为36.92 ± 15.43 ng/ml，健康对照组为21.71 ± 11.36 ng/ml。与健康人相比，AA患者中HMGB-1的水平显著更高，推断HMGB-1可能在AA的诊断中是有用的。使用HMGB-1，特别是在WBC计数正常的患者中，将减少不必要的探索次数。
The aim of this prospective study was therefore to evaluate the diagnostic value of preoperative serum High Mobility Group Box Protein-1 (HMGB-1) levels in patients with Acute Appendicitis (AA) who show normal white blood cell count (WBC) counts. Our study was carried out from October 2010 through November 2010 and included 20 healthy control group participants and 60 patients who presented at the emergency department of Erzurum Training and Research Hospital in Turkey with acute abdominal pain complaints, who were pathologically diagnosed with AA after laparotomy, and who agreed to participate in the study. Of the 60 patients who underwent appendectomies, 36 were male and 24 were female, and of the healthy group, 12 were male and 8 female. The age averages of the patients in Groups 1, 2 and 3 were, respectively, 31.3+15.4, 34.0+16.3 and 31.0+13.1 years. The WBC averages of Groups 1, 2 and 3 were, respectively, 7.41+2.02 (x109/L), 15.71+2.85 (x109/L) and 8.51+1.84 (x109/L). The HMGB-1 levels for Groups 1 (healthy persons), 2 (AA patients with high WBC counts ) and 3 (AA patients with normal WBC counts) were, respectively, 21.71 ± 11.36, 37.28+13.37 and 36.5 ± 17.73 ng/ml. The average HMGB-1 level of the patients with AA was 36.92 ± 15.43 ng/ml while the average HMGB-1 value of the healthy group was 21.71 ± 11.36 ng/ml. The significantly higher levels of HMGB-1 in AA patients compared to healthy persons infer that HMGB-1 might be useful in the diagnosis of AA. Use of HMGB-1, especially in patients with normal WBC counts, will reduce the number of unnecessary explorations.
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影响因子：
64.8
作者：
Scaffidi, P;Misteli, T;Bianchi, ME
通讯作者：
Bianchi, ME
DOI：
10.1016/s1743-9191(06)60050-2
发表时间：
2004-01-01
期刊：
International journal of surgery (London, England)
影响因子：
--
作者：
Amalesh, T;Shankar, M;Shankar, R
通讯作者：
Shankar, R
影响因子：
6.7
作者：
Hatada, T;Wada, H;Maruyama, I
通讯作者：
Maruyama, I
影响因子：
2.6
作者：
Tzanakis, NE;Efstathiou, SP;Nikiteas, NI
通讯作者：
Nikiteas, NI
影响因子：
2.2
作者：
Albayrak, Ayse;Uyanik, Muhammet H.;Uslu, Hakan
通讯作者：
Uslu, Hakan