A new chiral C1-symmetric NHC-catalyzed addition to α-aryl substituted α,β-disubstituted enals: enantioselective synthesis of fully functionalized dihydropyranones.
A new chiral C1-symmetric NHC-catalyzed addition to α-aryl substituted α,β-disubstituted enals: enantioselective synthesis of fully functionalized dihydropyranones.
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DOI：
10.1039/c5cc00118h
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发表时间：
2015-02
影响因子：
4.9
通讯作者：
Hong Lu;Jin-Yu Liu;Chen-Guang Li;Jun-Bing Lin;Yong‐Min Liang;Peng‐Fei Xu
中科院分区：
文献类型：
--
作者：
Hong Lu;Jin-Yu Liu;Chen-Guang Li;Jun-Bing Lin;Yong‐Min Liang;Peng‐Fei Xu
通过高活性酰基偶氮中间体，成功制备了第一个nhc催化α-芳基取代α，β-二取代不饱和醛的对映选择性活化。新合成的c1对称双芳基饱和咪唑具有较强的转化能力，可以高效、高产地合成具有良好对映选择性的全功能化二氢吡喃酮。
The first enantioselective NHC-catalyzed activation of α-aryl substituted α,β-disubstituted unsaturated aldehyde is successfully developed via a highly-active acyl azolium intermediate. The new C1-symmetric biaryl-saturated imidazolium exhibits a superior ability to enable previously unavailable transformation, and the corresponding fully functionalized dihydropyranones are efficiently synthesized in high yields with excellent enantioselectivities.