Apparent diffusion coefficient and fractional anisotropy in spinal cord: Age and cervical spondylosis-related changes
Apparent diffusion coefficient and fractional anisotropy in spinal cord: Age and cervical spondylosis-related changes
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DOI：
10.1002/jmri.20357
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发表时间：
2005-07-01
影响因子：
4.4
通讯作者：
Maier, SE
中科院分区：
文献类型：
--
作者：
Mamata, H;Jolesz, FA;Maier, SE
目的：目的：研究正常脊髓和颈椎病患者脊髓的表观弥散系数（ADC）和各向异性分数（FA）随年龄的变化。线扫描扩散张量图像是在1.5特斯拉全身扫描仪使用相控阵脊柱线圈。在矢状面测量ADC值和FA值。结果：正常脊髓在较宽的C2-C3水平的平均ADC值为0.81 ± 0.03 μ m（2）/msec，在较窄的C4-C7水平的平均ADC值为0.75 ± 0.06 μ m（2）/msec。相应水平的FA分别为0.70 +/- 0.05和0.66 +/- 0.03。ADC值与年龄呈正相关（斯皮尔曼，r = 0.242），FA值与年龄呈负相关（斯皮尔曼，r = -0.244）。54%的椎弓根病患者椎管狭窄水平ADC值较正常脊髓水平升高（P < 0.001），FA值较正常脊髓水平降低（P < 0.001）。T2加权像上高信号病灶的平均ADC和FA分别为1.28 ± 0.33 μ m（2）/mscc和0.46 ± 0.12.Conclusion：正常脊髓的ADC随着年龄的增长而增加，FA随着年龄的增长而减少。在具有脊髓病临床症状的颈椎病病例的脊髓中测量到ADC升高和FA降低。
Purpose: To present the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) change with age in the normal spinal cord and in cervical spondylosis.Materials and Methods: A total of 11 normal volunteers and 79 cervical spondylosis patients entered this study. Line scan diffusion tensor images were obtained in a 1.5-Tesla whole-body scanner using a phased-array spine coil. The ADC and FA values were measured on a sagittal section. Spearman correlation of ADC/FA vs. age for normal spinal cord was calculated.Results: The mean ADC of the normal spinal cord was 0.81 +/- 0.03 mu m(2)/msec at the relatively wide C2-C3 level and 0.75 +/- 0.06 mu m(2) /msec at the more narrow C4-C7 level. The FA at the corresponding level was 0.70 +/- 0.05 and 0.66 +/- 0.03, respectively. With age, ADC showed positive correlation (Spearman, r = 0.242) and FA exhibited negative correlation (Spearman, r = -0.244). A total of 54% of all spondylosis cases showed elevated ADC (P < 0.001) and decreased FA (P < 0.001) at the stenotic spinal canal level compared with the normal spinal cord. The average ADC and FA of high-signal lesions on T2-weighted images (seven patients) were 1.28 +/- 0.33 mu m(2)/mscc and 0.46 +/- 0.12, respectively.Conclusion: ADC increases and FA decreases with age in the normal spinal cord. Elevated ADC and reduced FA were measured in the spinal cord of spondylosis cases with clinical symptoms of myelopathy.