Effects of Tourniquet Ischemia on Current Perception Thresholds in Healthy Volunteers
Effects of Tourniquet Ischemia on Current Perception Thresholds in Healthy Volunteers
复制标题
止血带缺血对健康志愿者电流感知阈值的影响
作者：
Georgeann C. Baron;G. Irving
摘要：使用自动电诊断感觉神经传导阈值（sNCT）测试评价了健康志愿者中止血带缺血/压迫的神经选择性效应。sNCT评估生成可靠、无痛的电流感知阈值（CPT）测量。使用3种不同频率5 Hz、250 Hz和2 kHz的恒定交流正弦波形刺激进行标准化CPT测量（NeurometerEG CPT/C Neurotron，Inc.巴尔的摩，马里兰州）在基线和止血带缺血5、10、15和20分钟后以及止血带释放后30分钟从10名个体中获得。分析数据以确定CPT任何变化的显著性。在2000 Hz和250 Hz下止血带缺血15分钟和20分钟后，CPT的增加达到统计学显著性。5 Hz CPT测量值无显著变化。本研究的结果证明了sNCT试验能够量化之前描述的止血带缺血对感觉神经功能的不同神经选择性影响。证明继发于止血带缺血的2000 Hz和250 Hz CPT值在统计学上显著增加，而5 Hz CPT值无变化，这与以下理解一致：2000 Hz正弦波刺激激活大的有髓感觉纤维，250 Hz正弦波刺激激活小的有髓感觉纤维，5 Hz正弦波刺激激活小的无髓感觉纤维。
Abstract: The neuroselective effects of tourniquet isch‐ emia/compression in healthy volunteers were evaluated using the automated electrodiagnostic sensory Nerve Conduction Threshold (sNCT) test. The sNCT evaluation generates reliable, painless Current Perception Threshold (CPT) measures. Standardized CPT measures using constant alternating current sinusoid waveform stimulus at 3 different frequencies 5 Hz, 250 Hz, and 2 kHz (NeurometerEG CPT/C Neurotron, Inc. Baltimore, MD) were obtained from 10 individuals at baseline and after 5, 10, 15, and 20 minutes of tourniquet ischemia and 30 minutes post‐tourniquet release. The data were analyzed to determine the significance of any changes in CPTs. Increases in CPTs after 15 and 20 minutes of tourniquet ischemia at 2000 Hz and 250 Hz reached statistical significance. There were no significant changes in 5 Hz CPT measures. The results of this study demonstrate the ability of the sNCT test to quantify previously described differential neuroselective effects of tourniquet ischemia on sensory nerve function. Demonstration of statistically significant increases in CPT values at 2000 Hz and 250 Hz secondary to tourniquet ischemia, with no change in 5 Hz CPT values, is consistent with the understanding that 2000 Hz sine wave stimuli activate the large myelinated sensory fibers, 250 Hz sine wave stimuli activate small myelinated sensory fibers, and 5 Hz sine wave stimuli activate small unmyelinated sensory fibers.