Disruption of PAX6 function in mice homozygous for the Pax6(Sey-1Neu) mutation produces abnormalities in the early development and regionalization of the diencephalon
Disruption of PAX6 function in mice homozygous for the Pax6(Sey-1Neu) mutation produces abnormalities in the early development and regionalization of the diencephalon
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DOI：
10.1016/s0925-4773(97)00055-5
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发表时间：
1997-06-01
影响因子：
2.6
通讯作者：
Hogan, BLM
中科院分区：
文献类型：
--
作者：
Grindley, JC;Hargett, LK;Hogan, BLM
Pax 6在小鼠胚胎间脑中的表达在前后和背腹侧都受到限制，在前体节边界发生水平变化。Pax 6突变纯合子的小眼（Pax 6（Sey-1 Neu））小鼠在早期前脑发育中有多种缺陷。在Pax 6（Sey-1 Neu）/Pax 6（Sey-1 Neu）小鼠间脑中，存在明显的边界扩大（前体p2和p3之间的边界区域）和p1-p2边界模糊。PAX 6功能也是中脑-pi边界处的后连合的正常发育所需的。在间脑后部，PAX 6似乎调节其自身的转录，以及Wnt 7 b的转录。在P2和P3，腹侧标记比正常情况下更多地表达于背侧，并且这伴随着P3中的齿状回的尺寸减小。因此，PAX 6对间脑的正常发育和区域化至关重要。(C)1997 Elsevier Science爱尔兰有限公司
Pax6 expression in the diencephalon of the mouse embryo is restricted both antero-posteriorly and dorso-ventrally, with changes in level occurring at prosomere boundaries. Small eye (Pax6(Sey-1Neu)) mice homozygous for Pax6 mutations have multiple defects in early forebrain development. In the diencephalon of Pax6(Sey-1Neu)/Pax6(Sey-1Neu) mice there is an apparent enlargement of the zona limitans (the boundary region between prosomeres p2 and p3), and a blurring of the p1-p2 boundary. PAX6 function is also required for the normal development of the posterior commissure at the midbrain-pi boundary. In the posterior diencephalon PAX6 appears to regulate its own transcription, and that of Wnt7b. In p2 and p3, ventral markers are expressed more dorsally than normal, and this is accompanied in p3 by a reduction in the size of the zona incerta. Thus, PAX6 is essential for the normal development and regionalization of the diencephalon. (C) 1997 Elsevier Science Ireland Ltd.