Nasal vaccines: solutions for respiratory infectious diseases
Nasal vaccines: solutions for respiratory infectious diseases
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DOI：
10.1016/j.molmed.2022.10.009
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发表时间：
2022-11
影响因子：
13.6
通讯作者：
Rika Nakahashi-Ouchida;K. Fujihashi;Y. Kurashima;Y. Yuki;H. Kiyono
中科院分区：
文献类型：
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作者：
Rika Nakahashi-Ouchida;K. Fujihashi;Y. Kurashima;Y. Yuki;H. Kiyono
鼻疫苗在粘膜表面和全身诱导病原体特异性双重保护性免疫。因此，鼻疫苗既可以预防病原体入侵，又可以降低疾病的严重程度。由于这些特征，鼻用疫苗被认为是预防包括COVID-19在内的呼吸道传染病的下一代工具。然而，鼻疫苗必须克服关键的安全性问题，因为中枢神经系统（CNS）通过位于鼻腔旁边的嗅球在解剖学上接近。本文综述了目前开发安全有效的鼻用疫苗和给药系统的努力，以及它们在预防呼吸道感染中的临床应用。我们还讨论了关于鼻用疫苗安全性的各种问题，并介绍了一个评估它们的系统。
Nasal vaccines induce pathogen-specific dual protective immunity at mucosal surfaces and systemically throughout the body. Consequently, nasal vaccines both prevent pathogen invasion and reduce disease severity. Because of these features, nasal vaccines are considered to be a next-generation tool for preventing respiratory infectious diseases, including COVID-19. However, nasal vaccines must overcome key safety concerns given the anatomic proximity of the central nervous system (CNS) via the olfactory bulbs which lie next to the nasal cavity. This review summarizes current efforts to develop safe and effective nasal vaccines and delivery systems, as well as their clinical applications for the prevention of respiratory infections. We also discuss various concerns regarding the safety of nasal vaccines and introduce a system for evaluating them.