Antigenicity and reactogenicity of influenza A/USSR/77 virus vaccine in children--a multicentered evaluation of dosage and safety.
Antigenicity and reactogenicity of influenza A/USSR/77 virus vaccine in children--a multicentered evaluation of dosage and safety.
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儿童甲型/苏联/77 流感病毒疫苗的抗原性和反应原性——剂量和安全性的多中心评价。
DOI：
10.1093/clinids/5.4.758
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Taber,LH
中科院分区：
文献类型：
--
作者：
Wright,PF;Cherry,JD;Foy,HM;Glezen,WP;Hall,CB;McIntosh,K;Monto,AS;Parrott,RH;Portnoy,B;Taber,LH
对358名儿童和青少年进行了单价A/USSR/77 （H1N1）和三价A/USSR/77 （H1N1）、A/Texas/77 （H3N2）和B/Hong Kong/72流感病毒灭活疫苗的临床试验。13岁以下的儿童只接种了分裂病毒疫苗。在研究参与者中未观察到严重的局部或全身反应。需要两剂含有7-20µg A/苏联/77 （H1N1）病毒抗原的疫苗才能达到血凝素抑制（HAI）抗体>1:40的血清滴度。然而，单次剂量含有7-20µg A/Texas/77 （H3N2）或B/Hong Kong/72抗原刺激血清HAI抗体水平为1:40。
Clinical trials of monovalent A/USSR/77 (H1N1) and trivalent A/USSR/77 (H1N1), A/Texas/77 (H3N2), and B/Hong Kong/72 inactivated influenza virus vaccines were carried out in 358children and adolescents. Only split-virus vaccines were administered to children younger than 13 years of age. No serious local or systemic reactions were observed among the study participants. Two doses of vaccine containing 7–20 µg of the A/USSR/77 (H1N1) viral antigen were required to achieve serum titers of hemagglutinin-inhibiting (HAI) antibody >1:40. However, single doses containing 7–20 µg of the A/Texas/77 (H3N2) or B/Hong Kong/72 antigens stimulated serum HAI antibody levels of 1:40.