Targeting of adenosine receptors in ischemia-reperfusion injury.
Targeting of adenosine receptors in ischemia-reperfusion injury.
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DOI：
10.1517/14728222.2011.541441
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发表时间：
2011-01
影响因子：
5.8
通讯作者：
Okusa MD
中科院分区：
文献类型：
--
作者：
Laubach VE;French BA;Okusa MD
缺血再灌注损伤是移植后常见的临床问题，与心肌梗死和中风一样。IR引发炎症反应，导致快速组织损伤。腺苷是一种保护性的信号分子，通过四种不同的腺苷受体介导其生理反应。短半衰期、缺乏特异性和快速代谢限制了腺苷作为治疗剂的用途。因此，密集的研究工作集中在合成和实施特定的腺苷受体激动剂和拮抗剂，作为各种炎性病症包括IR损伤的潜在治疗剂。本文综述了目前对IR损伤的认识，重点是肺，心脏和肾脏，并检查研究，提高了我们对腺苷受体的作用和腺苷受体激动剂和拮抗剂预防IR损伤的治疗潜力的理解。读者将深入了解腺苷受体信号传导在IR损伤中的作用。目前没有专门针对IR损伤的临床治疗方法;然而，靶向特定腺苷受体可能在这方面提供治疗策略。
Ischemia-reperfusion (IR) injury is a common clinical problem after transplantation as well as myocardial infarction and stroke. IR initiates an inflammatory response leading to rapid tissue damage. Adenosine, produced in response to IR, is generally considered as a protective signaling molecule and elicits its physiological responses through four distinct adenosine receptors. The short half-life, lack of specificity, and rapid metabolism limits the use of adenosine as a therapeutic agent. Thus intense research efforts have focused on the synthesis and implementation of specific adenosine receptor agonists and antagonists as potential therapeutic agents for a variety of inflammatory conditions including IR injury. This review summarizes current knowledge on IR injury with a focus on lung, heart, and kidney, and examines studies that have advanced our understanding of the role of adenosine receptors and the therapeutic potential of adenosine receptor agonists and antagonists for the prevention of IR injury. The reader will gain insight into the role of adenosine receptor signaling in IR injury. No clinical therapies are currently available that specifically target IR injury; however, targeting of specific adenosine receptors may offer therapeutic strategies in this regard.
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影响因子：
19.6
作者：
Awad, Alaa S.;Rouse, Michael;Huang, Liping;Vergis, Amy L.;Reutershan, Joerg;Cathro, Helen P.;Linden, Joel;Okusa, Mark D.
通讯作者：
Okusa, Mark D.
影响因子：
4.6
作者：
Cassada, DC;Gangemi, JJ;Kern, JA
通讯作者：
Kern, JA
影响因子：
5.5
作者：
Epperson, Sara A.;Brunton, Laurence L.;Villarreal, Francisco
通讯作者：
Villarreal, Francisco
影响因子：
4.8
作者：
BABBITT, DG;VIRMANI, R;FORMAN, MB
通讯作者：
FORMAN, MB
DOI：
10.1152/ajpgi.00041.2009
发表时间：
2009-08-01
影响因子：
4.5
作者：
Cao, Zongxian;Yuan, Youzhong;Billiar, Timothy R.
通讯作者：
Billiar, Timothy R.