Physiological determinants of pulmonary gas exchange kinetics during exercise.
Physiological determinants of pulmonary gas exchange kinetics during exercise.
复制标题
运动期间肺气体交换动力学的生理决定因素。
DOI：
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发表时间：
1990
影响因子：
4.1
通讯作者：
S. Ward
中科院分区：
文献类型：
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作者：
B. Whipp;S. Ward
我们考虑了对施加作业率曲线的最佳选择，再加上对肺气体交换反应模式的严格的、统计上合理的分析，使得组装一个包含肌肉、循环和气体储存的比例作用的控制模型成为可能。可以将增益、时间常数和延迟分配给响应的分量，并评估其线性。这些技术还使研究人员能够检查不太了解的、甚至是意想不到的反应模式的特征。最近对分析运动的非稳定状态的兴趣--在正常受试者和气体交换缺陷患者中--导致了对亚阈值动态的更好的理解。在乳酸阈值以上的工作速率下，更复杂的动力学到目前为止还没有得到很好的描述，因此也很难被理解，仍然是控制系统技术应用于运动的肥沃领域。
We consider how the optimal selection of the profile of imposed work rate, coupled with rigorous, statistically justified analysis of the pattern of the pulmonary gas exchange response, makes it possible to assemble a control model incorporating the proportional role of the muscle, circulation, and gas stores. Gains, time constants, and delays may be assigned to the components of the response and its linearity assessed. These techniques also allow the investigator to examine the features of poorly understood and even unexpected response patterns. Recent interest in the analysis of the non-steady state of exercise-in normal subjects and in patients with gas exchange defects-has led to an improved understanding of the sub-threshold dynamics. At work rates above the lactate threshold, the more complex kinetics are to date poorly described, and hence poorly understood, remaining a fertile area for the application of control-systems techniques to exercise.