Multiscale network analysis identifies potential receptors for SARS-CoV-2 and reveals their tissue-specific and age-dependent expression.
Multiscale network analysis identifies potential receptors for SARS-CoV-2 and reveals their tissue-specific and age-dependent expression.
复制标题
DOI：
10.1002/1873-3468.14613
复制
发表时间：
2023-05
期刊：
影响因子：
3.5
通讯作者：
Zhang, Bin
中科院分区：
文献类型：
--
作者：
Forst, Christian V.;Zeng, Lu;Wang, Qian;Zhou, Xianxiao;Vatansever, Sezen;Xu, Peng;Song, Won-Min;Tu, Zhidong;Zhang, Bin
2019冠状病毒病（COVID-19）大流行已影响全球数千万人，并导致数十万人死亡。在这里，我们提出了一个全面的，多尺度的网络分析的转录反应的病毒。特别是，我们专注于被病毒劫持以获得优势的关键调节因子、细胞受体和宿主过程。ACE 2控制的过程涉及CD 300 e（TYROBP受体）作为关键调节因子和IL-2促炎细胞因子信号传导的激活。我们进一步研究了这些受体在不同组织中的年龄依赖性。总之，这项研究为SARS-CoV-2感染期间的基因调控组织以及COVID-19相关细胞受体的组织特异性、年龄依赖性表达提供了新的见解。2019冠状病毒病（COVID-19）大流行已影响全球数亿人，并导致数百万人死亡。我们对SARS-CoV-2的转录、年龄依赖性反应进行了多尺度网络分析，并揭示了细胞表面受体对衰老和SARS-CoV-2的反应之间的新关系。这些结果为理解SARS-CoV-2感染的分子机制铺平了道路。
The coronavirus disease 2019 (COVID‐19) pandemic has affected tens of millions of individuals and caused hundreds of thousands of deaths worldwide. Here, we present a comprehensive, multiscale network analysis of the transcriptional response to the virus. In particular, we focused on key regulators, cell receptors, and host processes that were hijacked by the virus for its advantage. ACE2‐controlled processes involved CD300e (a TYROBP receptor) as a key regulator and the activation of IL‐2 pro‐inflammatory cytokine signaling. We further investigated the age dependency of such receptors in different tissues. In summary, this study provides novel insights into the gene regulatory organization during the SARS‐CoV‐2 infection and the tissue‐specific, age‐dependent expression of the cell receptors involved in COVID‐19. The coronavirus disease 2019 (COVID‐19) pandemic has affected hundreds of millions of individuals and caused millions of deaths worldwide. We perform a multiscale network analysis of the transcriptional, age‐dependent response to SARS‐CoV‐2 and reveal a novel relationship between cell surface receptor responses to ageing and SARS‐CoV‐2. The results pave the way for understanding the molecular mechanisms of the SARS‐CoV‐2 infection.
登录
查看更多内容
DOI：
10.1126/science.abd3072
发表时间：
2020-11-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Daly JL;Simonetti B;Klein K;Chen KE;Williamson MK;Antón-Plágaro C;Shoemark DK;Simón-Gracia L;Bauer M;Hollandi R;Greber UF;Horvath P;Sessions RB;Helenius A;Hiscox JA;Teesalu T;Matthews DA;Davidson AD;Collins BM;Cullen PJ;Yamauchi Y
通讯作者：
Yamauchi Y
DOI：
10.1073/pnas.1808790115
发表时间：
2018-11-13
影响因子：
11.1
作者：
Bausch-Fluck D;Goldmann U;Müller S;van Oostrum M;Müller M;Schubert OT;Wollscheid B
通讯作者：
Wollscheid B
遗传对人体组织基因表达的影响。
影响因子：
64.8
作者：
GTEx Consortium;Laboratory, Data Analysis &Coordinating Center (LDACC)—Analysis Working Group;Statistical Methods groups—Analysis Working Group;Enhancing GTEx (eGTEx) groups;NIH Common Fund;NIH/NCI;NIH/NHGRI;NIH/NIMH;NIH/NIDA;Biospecimen Collection Source Site—NDRI;Biospecimen Collection Source Site—RPCI;Biospecimen Core Resource—VARI;Brain Bank Repository—University of Miami Brain Endowment Bank;Leidos Biomedical—Project Management;ELSI Study;Genome Browser Data Integration &Visualization—EBI;Genome Browser Data Integration &Visualization—UCSC Genomics Institute, University of California Santa Cruz;Lead analysts:;Laboratory, Data Analysis &Coordinating Center (LDACC):;NIH program management:;Biospecimen collection:;Pathology:;eQTL manuscript working group:;Battle A;Brown CD;Engelhardt BE;Montgomery SB
通讯作者：
Montgomery SB
病毒逃避干扰素的十种策略。
影响因子：
30.3
作者：
García-Sastre A
通讯作者：
García-Sastre A
影响因子：
64.8
作者：
Delorey TM;Ziegler CGK;Heimberg G;Normand R;Yang Y;Segerstolpe Å;Abbondanza D;Fleming SJ;Subramanian A;Montoro DT;Jagadeesh KA;Dey KK;Sen P;Slyper M;Pita-Juárez YH;Phillips D;Biermann J;Bloom-Ackermann Z;Barkas N;Ganna A;Gomez J;Melms JC;Katsyv I;Normandin E;Naderi P;Popov YV;Raju SS;Niezen S;Tsai LT;Siddle KJ;Sud M;Tran VM;Vellarikkal SK;Wang Y;Amir-Zilberstein L;Atri DS;Beechem J;Brook OR;Chen J;Divakar P;Dorceus P;Engreitz JM;Essene A;Fitzgerald DM;Fropf R;Gazal S;Gould J;Grzyb J;Harvey T;Hecht J;Hether T;Jané-Valbuena J;Leney-Greene M;Ma H;McCabe C;McLoughlin DE;Miller EM;Muus C;Niemi M;Padera R;Pan L;Pant D;Pe'er C;Pfiffner-Borges J;Pinto CJ;Plaisted J;Reeves J;Ross M;Rudy M;Rueckert EH;Siciliano M;Sturm A;Todres E;Waghray A;Warren S;Zhang S;Zollinger DR;Cosimi L;Gupta RM;Hacohen N;Hibshoosh H;Hide W;Price AL;Rajagopal J;Tata PR;Riedel S;Szabo G;Tickle TL;Ellinor PT;Hung D;Sabeti PC;Novak R;Rogers R;Ingber DE;Jiang ZG;Juric D;Babadi M;Farhi SL;Izar B;Stone JR;Vlachos IS;Solomon IH;Ashenberg O;Porter CBM;Li B;Shalek AK;Villani AC;Rozenblatt-Rosen O;Regev A
通讯作者：
Regev A