Having lived on a farm and protection against allergic diseases in Australia
Having lived on a farm and protection against allergic diseases in Australia
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DOI：
10.1046/j.1365-2222.2001.01070.x
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发表时间：
2001-04-01
影响因子：
6.1
通讯作者：
Peat, JK
中科院分区：
文献类型：
--
作者：
Downs, SH;Marks, GB;Peat, JK
背景：北方农民的孩子比其他孩子有较低的过敏症、花粉热和哮喘的患病率。澳大利亚农场的规模和经营方式与欧洲不同，儿童过敏性疾病的患病率更高。目的探讨澳大利亚儿童在农场生活是否与过敏性疾病的低风险有关。（n = 1500），7-12岁，来自两个乡镇：混合农业区的瓦格加瓦格加和农作物种植区的莫里。父母回答了一份调查问卷，孩子们有一个皮肤点刺试验atopy.Results百分之二十的儿童生活在一个农场至少1年。生活在农场的影响在城镇之间存在差异（P < 0.001）。在Wagga中，它与特应性的较低风险相关（调整后的比值比（aOR）0.47，95%置信区间（CI）0.32-0.72），但在Moree中不相关（aOR 0.97，95% CI 0.62-1.53）。来自Wagga的儿童更有可能生活在畜牧场比儿童Moree（26.1%vs.9.1%，95%CI差异8.9-25.4）。结论生活在澳大利亚的农场可以保护儿童免受特应性。需要进一步研究，以确定与农场动物有关的可能的保护机制，或确定保护作用是否可以用其他相关的暴露来解释。
Background Farmers' children in northern Europe have a lower prevalence of atopy, hay fever and asthma than other children. Farms in Australia differ in scale and operation from those in Europe and the prevalence of allergic diseases in children is higher.Objective To investigate whether having lived on a farm as a child in Australia is associated with a lower risk of allergic diseases.Methods Cross-sectional study of children (n = 1500) aged 7-12 years from two rural towns: Wagga Wagga in a mixed farming region, and Moree in a crop farming region. Parents answered a questionnaire and children had a skin prick test for atopy.Results Twenty percent of children had lived on a farm for at least 1 year. The effect of having lived on a farm differed between the towns (P < 0.001). It was associated with a lower risk of atopy in Wagga (adjusted odds ratio (aOR) 0.47, 95% confidence interval (CI) 0.32-0.72) but not in Moree (aOR 0.97, 95% CI 0.62-1.53). Children from Wagga were more likely to have lived on a livestock farm than children from Moree (26.1% vs. 9.1%, 95% CI for the difference 8.9-25.4).Conclusion Having lived on a farm in Australia can confer protection against atopy in children. Further studies are needed to identify possible protective mechanisms associated with farm animals or to establish whether the protective effect is explained by other related exposures.