Reduction of inflammation and preservation of neurological function by anti-CD52 therapy in murine experimental autoimmune encephalomyelitis
Reduction of inflammation and preservation of neurological function by anti-CD52 therapy in murine experimental autoimmune encephalomyelitis
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DOI：
10.1016/j.jneuroim.2015.05.018
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发表时间：
2015-08-15
影响因子：
3.3
通讯作者：
Siders, William M.
中科院分区：
文献类型：
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作者：
Turner, Michael J.;Pang, Petti T.;Siders, William M.
阿仑妥珠单抗是一种针对人CD52的单克隆抗体，用于治疗多发性硬化症。为了表征抗CD52给药的影响，研究人员在多发性硬化症EAE小鼠模型中产生了一种针对小鼠CD52的单克隆抗体（抗mucd52），并对其进行了评估。中枢神经系统检查显示浸润淋巴细胞减少，脱髓鞘和轴突丢失。电生理评估显示脊髓轴突传导保留。这些发现表明抗cd52治疗可能有助于保持中枢神经系统的完整性。(C) 2015年作者。这是一篇基于CC by - nc - nd许可的开放获取文章。
Alemtuzumab, a monoclonal antibody directed against human CD52, is used in the treatment of MS. To characterize the impact of anti-CD52 administration, a monoclonal antibody to mouse CD52 (anti-muCD52) was generated and evaluated in EAE mouse models of MS. A single course of anti-muCD52 provided a therapeutic benefit accompanied by a reduction in the frequency of autoreactive T lymphocytes and production of pro-inflammatory cytokines. Examination of the CNS revealed a decrease in infiltrating lymphocytes, demyelination and axonal loss. Electrophysiological assessment showed preservation of axonal conductance in the spinal cord. These findings suggest that anti-CD52 therapy may help preserve CNS integrity. (C) 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license.