Prospects of Cell Therapy for Disorders of Myelin
Prospects of Cell Therapy for Disorders of Myelin
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DOI：
10.1196/annals.1444.014
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发表时间：
2008-01-01
期刊：
影响因子：
--
通讯作者：
Goldman, Steven A.
中科院分区：
文献类型：
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作者：
Ben-Hur, Tamir;Goldman, Steven A.
干细胞生物学的最新进展提高了人们的期望，即中枢神经系统的疾病和损伤都可能通过细胞移植得到改善。特别是，细胞疗法已被研究用于诱导髓鞘疾病的有效髓鞘再生，包括髓鞘形成和维持的主要儿科疾病以及儿童和成人的获得性脱髓鞘。两大类疾病的潜在细胞治疗方法包括髓鞘原性替代的传递和残余少突胶质细胞祖细胞的动员，作为刺激内源性修复的一种手段；然后根据疾病目标选择模式。在这篇综述中，我们考虑了基于细胞的治疗策略在髓鞘疾病中的潜在应用，强调了这种治疗方法的前景以及问题和潜在的危险。
Recent advances in stem cell biology have raised expectations that both diseases of, and injuries to, the central nervous system may be ameliorated by cell transplantation. In particular, cell therapy has been studied for inducing efficient remyelination in disorders of myelin, including both the largely pediatric disorders of myelin formation and maintenance and the acquired demyelinations of both children and adults. Potential cell-based treatments of two major groups of disorders include both delivery of myelinogenic replacements and mobilization of residual oligodendrocyte progenitor cells as a means of stimulating endogenous repair; the choice of modality is then predicated upon the disease target. In this review we consider the potential application of cell-based therapeutic strategies to disorders of myelin, highlighting the promises as well as the problems and potential perils of this treatment approach.