Supported membranes: Scientific and practical applications
Supported membranes: Scientific and practical applications
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DOI：
10.1126/science.271.5245.43
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发表时间：
1996-01-05
期刊：
影响因子：
56.9
通讯作者：
Sackmann, E
中科院分区：
文献类型：
--
作者：
Sackmann, E
描述了负载型脂蛋白双层的科学和实际应用。膜可以通过超薄的水层或软聚合物垫共价耦合到固体或与固体分离，后者系统保持自由双层的结构和动力学性质，形成一类生物膜模型，允许应用多种表面敏感技术，它们形成多种低维复杂流体模型，可用于研究界面力和润湿现象，并使幻影细胞的设计能够探索锁定和关键力(例如受体-配体结合)和细胞黏附的普遍力的相互作用，实际应用是设计电光器件上生物传感器的(高选择性)受体表面或无机固体的生物功能化。
Scientific and practical applications of supported lipid-protein bilayers are described. Membranes can be covalently coupled to or separated from solids by ultrathin layers of water or soft polymer cushions, The latter systems maintain the structural and dynamic properties of free bilayers, forming a class of models of biomembranes that allow the application of a manifold of surface-sensitive techniques, They form versatile models of low-dimensionality complex fluids, which can be used to study interfacial forces and wetting phenomena, and enable the design of phantom cells to explore the interplay of lock-and-key forces (such as receptor-ligand binding) and universal forces for cell adhesion, Practical applications are the design of (highly selective) receptor surfaces of biosensors on electrooptical devices or the biofunctionalization of inorganic solids.