Relationships between the biological and physicochemical properties of series of compounds.
Relationships between the biological and physicochemical properties of series of compounds.
复制标题
系列化合物的生物和理化性质之间的关系。
DOI：
10.1021/jm00237a001
复制
发表时间：
1975
影响因子：
7.3
通讯作者：
R. M. Hyde
中科院分区：
文献类型：
--
作者：
R. M. Hyde
An equilibrium model is described for relationships between the biological activity and the physicochemical properties of compounds in a congeneric series. An equation derived from the model is of the form, log C = log (a + 10-alpha) = b, where C is the total molar concentration of drug to produce a standard response, alpha ia a parameter of the form log K where K is an equilibrium constant, and a and b are coefficients. This equation provides a plausible fit to some nonlinear observations which have been studied.
