Immune responses to stress in rheumatoid arthritis and psoriasis
Immune responses to stress in rheumatoid arthritis and psoriasis
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DOI：
10.1093/rheumatology/keu221
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发表时间：
2014-10-01
期刊：
影响因子：
5.5
通讯作者：
Evers, Andrea W. M.
中科院分区：
文献类型：
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作者：
de Brouwer, Sabine J. M.;van Middendorp, Henriet;Evers, Andrea W. M.
Objective.压力是可能加剧慢性炎症性疾病（如RA和银屑病）进展的因素之一。我们探索性地比较了急性应激对RA患者、银屑病患者和健康受试者的疾病进展和/或应激反应中循环细胞因子水平的影响。RA患者、银屑病患者和健康对照者接受标准化心理社会应激测试（Trier社会应激测试）。在应激试验前后测定循环细胞因子（IL-1 β、IL-2、IL-4、IL-5、IL-6、IL-7、IL-8、IL-10、IFN-γ和TNF-α）的水平。RA患者除IL-8外，所有细胞因子的基线水平均显著升高。校正基线水平后，RA患者的IL-1b和IL-2水平高于银屑病患者和健康对照组。结果表明，RA患者对应激的免疫反应与银屑病患者或健康对照组不同。需要更多地了解压力，免疫参数和慢性炎症之间的复杂相互作用。
Objective. Stress is one of the factors that may exacerbate the progression of chronic inflammatory diseases such as RA and psoriasis. We exploratively compared the effects of acute stress on levels of circulating cytokines involved in disease progression and/or the stress response in patients with RA, patients with psoriasis and healthy subjects.Methods. Patients with RA, patients with psoriasis and healthy controls underwent a standardized psychosocial stress test (Trier Social Stress Test). Levels of circulating cytokines (IL-1 beta, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IFN-gamma and TNF-alpha) were measured before and after the stress test.Results. The baseline levels of all cytokines, except IL-8, were significantly higher in patients with RA. After correction for baseline levels, patients with RA showed higher stress-induced levels of IL-1b and IL-2 than patients with psoriasis and healthy controls.Conclusion. The results suggest that patients with RA have a different immune response to stress than patients with psoriasis or healthy controls. More needs to be learned about the complex interaction between stress, immune parameters and chronic inflammation.