The dynamics of energy metabolism in the tick embryo
The dynamics of energy metabolism in the tick embryo
复制标题
DOI：
10.1590/s1984-296120180051
复制
发表时间：
2018-09-01
期刊：
影响因子：
--
通讯作者：
Logullo, Carlos
中科院分区：
文献类型：
--
作者：
Martins, Renato;Ruiz, Newton;Logullo, Carlos
牛扁虱微体是一种体外寄生虫，可传播大量病原体，给养牛业造成相当大的损失，对牲畜造成重大损害。多年来，其生命周期的重要阶段，如胚胎，在很大程度上被研究人员忽视了。扁虱胚胎发育通常被描述为一个耗能的过程，维持细胞的增殖、分化和生长。在节肢动物的胚胎阶段，有母源代谢物的动员，以促进胚胎器官和组织的发育。胚胎发育后期糖原再合成被认为是胚胎完整性的有效指标。在牛壁虱R(B.(B.)在胚胎发育末期，糖原的再合成是通过糖异生途径的蛋白质降解来维持的。尽管在分子水平上对硬虱能量代谢的研究取得了新的进展，但在R.(B.)微加胚胎发生仍然知之甚少。本综述旨在描述母体-受精卵转变过程中碳水化合物代谢的调节机制，并确定可能的新靶点，以开发新的药物和其他防治措施。微加侵扰。
The cattle tick Rhipicephalus (Boophilus) microplus is an ectoparasite capable of transmitting a large number of pathogens, causing considerable losses in the cattle industry, with substantial damage to livestock. Over the years, important stages of its life cycle, such as the embryo, have been largely ignored by researchers. Tick embryogenesis has been typically described as an energy-consuming process, sustaining cell proliferation, differentiation, and growth. During the embryonic stage of arthropods, there is mobilization of metabolites of maternal origin for the development of organs and tissues of the embryo. Glycogen resynthesis in late embryogenesis is considered as an effective indicator of embryonic integrity. In the cattle tick R.(B. (B.) microplus, glycogen resynthesis is sustained by protein degradation through the gluconeogenesis pathway at the end of the embryonic period. Despite recent advancements in research on tick energy metabolism at the molecular level, the dynamics of nutrient utilization during R. (B.) microplus embryogenesis is still poorly understood. The present review aims to describe the regulatory mechanisms of carbohydrate metabolism during maternal-zygotic transition and identify possible new targets for the development of novel drugs and other control measures against R. (B.) microplus infestations.