Effects of repeated pup exposure on behavioral, neural, and adrenocortical responses to pups in male California mice (Peromyscus californicus).
Effects of repeated pup exposure on behavioral, neural, and adrenocortical responses to pups in male California mice (Peromyscus californicus).
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DOI：
10.1016/j.yhbeh.2017.02.008
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发表时间：
2017-04
影响因子：
3.5
通讯作者：
Saltzman W
中科院分区：
文献类型：
--
作者：
Horrell ND;Perea-Rodriguez JP;Harris BN;Saltzman W
在双亲哺乳动物中，促进雄性父母行为发生的因素还不太清楚。虽然父亲的荷尔蒙变化可能起作用，但以前与幼崽的经验也有牵连。我们评估了双亲加州小鼠（Peromyscus californicus）中先前暴露于幼鼠对父系反应的影响。我们分析了行为，神经和皮质酮的反应，幼崽在成年处女男性，第一次与小狗互动，成年处女男性，已暴露于小狗3次，每次20分钟，在前一周，和新的父亲。处女的对照组也用一种新的物体（大理石）进行了类似的测试。先前接触幼崽减少了处女接近幼崽和开始父亲照顾的潜伏期，并增加了父亲照顾的时间。对幼犬的反应在反复接触幼犬和新父亲的处女之间没有差异。相比之下，反复接触大理石没有任何影响。无论是基础皮质酮水平，也没有皮质酮水平急性幼犬或大理石暴露组之间的差异。最后，Fos的表达在内侧视前区，腹侧和背侧床核的终纹是较高的暴露后，小狗比大理石。然而，Fos表达没有受到先前暴露于这些刺激的影响。这些结果表明，以前的经验与幼崽可以促进雄性加州小鼠的父母的行为，在雌性啮齿类动物的研究结果相似，这种效果是不相关的普遍减少新恐惧症。
In biparental mammals, the factors facilitating the onset of male parental behavior are not well understood. While hormonal changes in fathers may play a role, prior experience with pups has also been implicated. We evaluated effects of prior exposure to pups on paternal responsiveness in the biparental California mouse (Peromyscus californicus). We analyzed behavioral, neural, and corticosterone responses to pups in adult virgin males that were interacting with a pup for the first time, adult virgin males that had been exposed to pups 3 times for 20 minutes each in the previous week, and new fathers. Control groups of virgins were similarly tested with a novel object (marble). Previous exposure to pups decreased virgins’ latency to approach pups and initiate paternal care, and increased time spent in paternal care. Responses to pups did not differ between virgins with repeated exposure to pups and new fathers. In contrast, repeated exposure to a marble had no effects. Neither basal corticosterone levels nor corticosterone levels following acute pup or marble exposure differed among groups. Finally, Fos expression in the medial preoptic area, and ventral and dorsal bed nucleus of the stria terminalis was higher following exposure to a pup than to a marble. Fos expression was not, however, affected by previous exposure to these stimuli. These results suggest that previous experience with pups can facilitate the onset of parental behavior in male California mice, similar to findings in female rodents, and that this effect is not associated with a general reduction in neophobia.