Effect of collagen and mineral content on the high-frequency ultrasonic properties of human cancellous bone
Effect of collagen and mineral content on the high-frequency ultrasonic properties of human cancellous bone
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DOI：
10.1007/s198-002-8334-7
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发表时间：
2002-01-01
影响因子：
4
通讯作者：
Rho, JY
中科院分区：
文献类型：
--
作者：
Hoffmeister, BK;Whitten, SA;Rho, JY
随着研究人员探索新的超声参数和不同超声频率的实用性，超声骨评估技术正在迅速发展。这项研究有三个主要目标。第一个是使用2.25 MHz宽带测量系统对正常人松质骨标本中的声速（SOS）和归一化宽带超声衰减（nBUA）进行体外测量。第二个是探索一个基于后向散射的参数称为表观积分后向散射（AIB）的效用。第三个目标是研究胶原蛋白和矿物质含量在影响这三个超声参数中的每一个中所起的作用。这是通过化学处理标本，以去除这两种重要的骨成分中的一种或另一种来实现的。我们的结果表明，在大多数情况下，SOS和nBUA相关良好（p
The technology surrounding ultrasonic bone assessment is evolving rapidly as investigators explore the utility of new ultrasonic parameters and different ultrasonic frequencies. This study had three main goals. The first was to perform in vitro measurements of the speed of sound (SOS) and normalized broadband ultrasonic attenuation (nBUA) in specimens of normal human cancellous bone using a 2.25 MHz broadband measurement system. The second was to explore the utility of a backscatter-based parameter called apparent integrated backscatter (AIB). The third goal was to investigate the roles that collagen and mineral content play in affecting each of these three ultrasonic parameters. This was accomplished by chemically treating the specimens to remove one or the other of these two important constituents of bone. Our results showed that in most cases SOS and nBUA correlated well (p