Moldable and Removable Wound Dressing Based on Dynamic Covalent Cross-Linking of Thiol-Aldehyde Addition
Moldable and Removable Wound Dressing Based on Dynamic Covalent Cross-Linking of Thiol-Aldehyde Addition
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基于硫醇-醛加成动态共价交联的可塑可移除伤口敷料
DOI：
10.1021/acsbiomaterials.9b00459
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发表时间：
2019
影响因子：
--
通讯作者：
Linyong Zhu
中科院分区：
文献类型：
--
作者：
Yujie Hua;Yibo Gan;Pei Li;Lei Song;Chunmeng Shi;Chunyan Bao;Yi Yang;Qiang Zhou;Qiuning Lin;Linyong Zhu
开发用于伤口敷料的可模制且可移除的凝胶技术变得非常令人期待。在此，我们描述了一种在氧化葡聚糖中生成适应性强且可溶解的 PEG-硫醇和醛基网络的简便方法。硫醇-醛加成反应的动态共价化学使水凝胶具有典型的流变行为，从而赋予水凝胶对于伤口覆盖的初始操作具有优异的适应性。添加游离硫醇化合物后，动态共价交联水凝胶将通过硫醇-半硫缩醛交换反应溶解。作为烫伤创面临时敷料的成功应用表明，基于硫醇醛加成反应的水凝胶具有适应性和溶解性，这对于生物医学领域具有重要意义。
The development of a moldable and removable gel technique for wound dressing is becoming highly desirable. Herein, we describe a facile method to generate an adaptable and dissolvable network of PEG-thiols and aldehyde groups in oxidized dextran. The dynamic covalent chemistry of the thiol-aldehyde addition reaction provides hydrogels with typical rheological behavior and thus endows the hydrogels with an excellent adaptability for the initial operation of wound coverage. Upon addition of free thiol compounds, the dynamic covalent cross-linked hydrogels will dissolve via thiol-hemithioacetal exchange reaction. The successful application as a temporary dressing for scalded wounds indicated the hydrogels had both adaptability and dissolvability based on the thiol-aldehyde addition reaction, which is significant for biomedical areas.