Increased Iron Deposition on Brain Quantitative Susceptibility Mapping Correlates with Decreased Cognitive Function in Alzheimer's Disease
Increased Iron Deposition on Brain Quantitative Susceptibility Mapping Correlates with Decreased Cognitive Function in Alzheimer's Disease
复制标题
大脑定量磁敏图上铁沉积的增加与阿尔茨海默氏病认知功能下降相关
DOI：
10.1021/acschemneuro.8b00194
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发表时间：
2018-07-01
影响因子：
5
通讯作者：
Ma, Guolin
中科院分区：
文献类型：
--
作者：
Du, Lei;Zhao, Zifang;Ma, Guolin
铁在深灰色中的过度积累相关结构是阿尔茨海默病（AD）患者的重要病理特征。定量磁化率成像（QSM）比其他基于成像的铁测量方式更具有特异性，并且允许对组织磁化率进行无创评估，这已被证明与脑铁水平具有良好的相关性。本研究旨在探讨轻、中度AD患者脑深部灰质核团的磁化率与简易精神状态检查量表（MMSE）和蒙特利尔认知功能评定量表（莫卡）认知功能的相关性。采用3.0 T磁共振成像（MRI）扫描仪对30例轻度和中度AD受试者和30例年龄和性别匹配的健康对照者进行扫描。用QSM定量分析尾状核（Cd）、壳核（Pt）、苍白球（Gp）、丘脑（Th）、红核（Rn）、黑质（Sn）和齿状核（Dn）等感兴趣区域的磁化率。AD患者双侧Cd、Pt敏感值显著高于对照组（P < 0.05）。相反，双侧Rn在AD中的易感性值显著低于对照组。无论性别和年龄，左侧Cd区磁化率的增加与MMSE评分和莫卡评分的降低显著相关（P < 0.05）。我们的研究表明，左镉的磁化率值可能被用作轻、中度AD疾病严重程度的生物标志物。
The excessive accumulation of iron in deep gray The correlation structures is an important pathological characteristic in patients with Alzheimer's disease (AD). Quantitative susceptibility mapping (QSM) is more specific than other imaging based iron measurement modalities and allows noninvasive assessment of tissue magnetic susceptibility, which has been shown to correlate well with brain iron levels. This study aimed to investigate the correlations between the magnetic susceptibility values of deep gray matter nuclei and the cognitive functions assessed by mini-mental state examination (MMSE) and Montreal cognitive assessment (MoCA) in patients with mild and moderate AD. Thirty subjects with mild and moderate AD and 30 age- and sex-matched healthy controls were scanned with a 3.0 T magnetic resonance imaging (MRI) scanner. The magnetic susceptibilities of the regions of interest (ROIs), including caudate nucleus (Cd), putamen (Pt), globus pallidus (Gp), thalamus (Th), red nucleus (Rn), substantia nigra (Sn), and dentate nucleus (Dn), were quantified by QSM. We found that the susceptibility values of the bilateral Cd and Pt were significantly higher in AD patients than the controls (P < 0.05). In contrast, bilateral Rn had significantly lower susceptibility values in AD than the controls. Regardless of gender and age, the increase of magnetic susceptibility in the left Cd was significantly correlated with the decrease of MMSE scores and MoCA scores (P < 0.05). Our study indicated that magnetic susceptibility value of left Cd could be potentially used as a biomarker of disease severity in mild and moderate AD.