Thalamo-cortical network activity during spontaneous migraine attacks
Thalamo-cortical network activity during spontaneous migraine attacks
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DOI：
10.1212/wnl.0000000000003327
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发表时间：
2016-11-15
期刊：
影响因子：
9.9
通讯作者：
Pierelli, Francesco
中科院分区：
文献类型：
--
作者：
Coppola, Gianluca;Di Renzo, Antonio;Pierelli, Francesco
目的：利用MRI对自发性偏头痛发作时丘脑-皮质网络和丘脑微结构的变化进行研究，同时利用弥散张量成像和独立分量分析研究相互连接的脑网络的静息状态功能。方法：13例未经治疗的无先兆偏头痛（MI）患者在发作期间接受3T MRI扫描，并与19名健康对照组（HC）进行比较。我们收集了2个选择的网络的静息状态数据，使用组独立成分（IC）分析识别。在相同的参与者中计算双侧丘脑的分数各向异性（FA）值，并与静息状态IC z评分相关。结果：与HC相比，MI的执行和背-腹侧注意网络之间的功能连接减少。在HC中，但在MI中，IC24 z分数越高，包括背-腹侧注意系统的相互连接区域，双侧丘脑FA值越低。在患者中，执行控制网络z得分越高，每月偏头痛天数越少。结论：这些结果为偏头痛发作时丘脑和大脑注意网络之间的异常连接提供了证据。这种异常可能伴随着已知的认知能力的严重损害，并表明后者可能随着发作频率的增加而恶化。
Objective: We used MRI to search for changes in thalamo-cortical networks and thalamic microstructure during spontaneous migraine attacks by studying at the same time structure with diffusion tensor imaging and resting state function in interconnected brain networks with independent component analysis.Methods: Thirteen patients with untreated migraine without aura (MI) underwent 3T MRI scans during an attack and were compared to a group of 19 healthy controls (HC). We collected resting state data in 2 selected networks identified using group independent component (IC) analysis. Fractional anisotropy (FA) values of bilateral thalami were calculated in the same participants and correlated with resting state IC z scores.Results: Functional connectivity between the executive and the dorso-ventral attention networks was reduced in MI compared to HC. In HC, but not in MI, the higher the IC24 z score, encompassing interconnected areas of the dorso-ventral attention system, the lower the bilateral thalamic FA values. In patients, the higher the executive control network z scores, the lower the number of monthly migraine days.Conclusions: These results provide evidence for abnormal connectivity between the thalamus and attentional cerebral networks at rest during migraine attacks. This abnormality could subtend the known ictal impairment of cognitive performance and suggests that the latter might worsen with increasing attack frequency.