Harm avoidance and risk of Alzheimer's disease.
Harm avoidance and risk of Alzheimer's disease.
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DOI：
10.1097/psy.0b013e3182302ale
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发表时间：
2011-10
影响因子：
3.3
通讯作者：
Bennett DA
中科院分区：
文献类型：
--
作者：
Wilson RS;Boyle PA;Buchman AS;Yu L;Arnold SE;Bennett DA
为了验证这一假设，即伤害回避，一种与行为抑制相关的特质，与患阿尔茨海默病的风险相关。共有791名年龄在55岁及以上的无痴呆症成年人完成了一项标准的自我报告伤害避免措施。然后，他们进行了年度评估，包括详细的认知测试和轻度认知障碍，痴呆症和阿尔茨海默病的临床分类。在对死亡者进行统一的神经病理学检查时，将神经炎性斑块、弥漫性斑块和神经纤维缠结的计数标准化，并结合起来产生疾病的病理学测量。在校正了年龄、性别和教育的分析中，估计了避免伤害与阿尔茨海默病发病率和相关结果的关系。在平均3.5年的年度观察中，98人（12.4%）发生了阿尔茨海默病。高水平的伤害回避（第90百分位）与阿尔茨海默病风险的两倍以上增加相关联，与低分数（第10百分位）相比。更高的伤害回避也与轻度认知障碍的发生率增加以及情节记忆、工作记忆和感知速度（但不是语义记忆或视觉空间能力）的更快下降相关。在116名死亡并接受大脑尸检的参与者中，伤害避免与斑块和缠结的复合测量无关。高水平的伤害回避特质，表明行为抑制的倾向，与发展阿尔茨海默病及其前兆轻度认知障碍的风险有关。
To test the hypothesis that harm avoidance, a trait associated with behavioral inhibition, is associated with risk of developing Alzheimer’s disease. A total of 791 adults aged 55 years and older without dementia completed a standard self report measure of harm avoidance. They then underwent annual evaluations that included detailed cognitive testing and clinical classification of mild cognitive impairment, dementia and Alzheimer’s disease. In a uniform neuropathologic examination of those who died, counts of neuritic plaques diffuse plaques, and neurofibrillary tangles were standardized and combined to yield a pathologic measure of disease. The relation of harm avoidance to incidence of Alzheimer’s disease and related outcomes was estimated in analyses adjusted for age, sex, and education. During a mean of 3.5 years of annual observation, 98 people (12.4%) developed incident Alzheimer’s disease. High level of harm avoidance (90th percentile) was associated with a more than twofold increase in risk of Alzheimer’s disease compared to a low score (10th percentile). Higher harm avoidance was also associated with increased incidence of mild cognitive impairment and more rapid decline in episodic memory, working memory, and perceptual speed (but not semantic memory or visuospatial ability). In 116 participants who died and underwent brain autopsy, harm avoidance was not related to a composite measure of plaques and tangles. High level of the harm avoidance trait, indicating a tendency toward behavioral inhibition, is related to risk of developing Alzheimer’s disease and its precursor, mild cognitive impairment.