Physical activity for cancer survivors: meta-analysis of randomised controlled trials.
Physical activity for cancer survivors: meta-analysis of randomised controlled trials.
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DOI：
10.1136/bmj.e70
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发表时间：
2012-01-30
期刊：
影响因子：
--
通讯作者：
Cheng KK
中科院分区：
文献类型：
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作者：
Fong DY;Ho JW;Hui BP;Lee AM;Macfarlane DJ;Leung SS;Cerin E;Chan WY;Leung IP;Lam SH;Taylor AJ;Cheng KK
目的系统评价成年癌症患者完成主要治疗后体力活动的效果。随机对照试验的Meta分析，由两名研究人员独立进行数据提取和质量评估。数据来源Pubmed、CINAHL和Google Scholar，从最早的一年到2011年9月。来自荟萃分析和综述的参考文献。研究选择随机对照试验，评估身体活动对已完成主要癌症治疗（激素治疗除外）的成年人的影响。结果共有34项随机对照试验，其中22项（65%）集中在乳腺癌患者中，我们的荟萃分析中有48项结局。22项研究评估了有氧运动，4项研究还包括阻力或力量训练。体力活动的中位持续时间为13周（范围3-60周）。大多数对照组被认为是久坐不动的或没有被指定锻炼。基于对乳腺癌患者的研究，体力活动与胰岛素样生长因子-I、卧推、腿部推举、疲劳、抑郁和生活质量的改善相关。当我们结合对不同类型癌症的研究时，我们发现身体质量指数（BMI），体重，峰值耗氧量，峰值功率输出，六分钟步行距离，右手握力和生活质量都有显着改善。研究异质性的来源包括年龄、研究质量、研究规模以及体力活动的类型和持续时间。发表偏倚并没有改变我们的结论。结论体力活动对乳腺癌患者治疗后的生理、身体成分、身体功能、心理结局和生活质量有积极的影响。当还包括乳腺癌以外的癌症患者时，体力活动与BMI和体重降低，峰值耗氧量和峰值功率输出增加以及生活质量改善相关。
Objective To systematically evaluate the effects of physical activity in adult patients after completion of main treatment related to cancer. Design Meta-analysis of randomised controlled trials with data extraction and quality assessment performed independently by two researchers. Data sources Pubmed, CINAHL, and Google Scholar from the earliest possible year to September 2011. References from meta-analyses and reviews. Study selection Randomised controlled trials that assessed the effects of physical activity in adults who had completed their main cancer treatment, except hormonal treatment. Results There were 34 randomised controlled trials, of which 22 (65%) focused on patients with breast cancer, and 48 outcomes in our meta-analysis. Twenty two studies assessed aerobic exercise, and four also included resistance or strength training. The median duration of physical activity was 13 weeks (range 3-60 weeks). Most control groups were considered sedentary or were assigned no exercise. Based on studies on patients with breast cancer, physical activity was associated with improvements in insulin-like growth factor-I, bench press, leg press, fatigue, depression, and quality of life. When we combined studies on different types of cancer, we found significant improvements in body mass index (BMI), body weight, peak oxygen consumption, peak power output, distance walked in six minutes, right handgrip strength, and quality of life. Sources of study heterogeneity included age, study quality, study size, and type and duration of physical activity. Publication bias did not alter our conclusions. Conclusions Physical activity has positive effects on physiology, body composition, physical functions, psychological outcomes, and quality of life in patients after treatment for breast cancer. When patients with cancer other than breast cancer were also included, physical activity was associated with reduced BMI and body weight, increased peak oxygen consumption and peak power output, and improved quality of life.