Influence of Partial Sleep Deprivation on Energy Balance and Insulin Sensitivity in Healthy Women
Influence of Partial Sleep Deprivation on Energy Balance and Insulin Sensitivity in Healthy Women
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DOI：
10.1159/000158874
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发表时间：
2008-10-01
期刊：
影响因子：
3.6
通讯作者：
Mueller, Manfred James
中科院分区：
文献类型：
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作者：
Bosy-Westphal, Anja;Hinrichs, Silvia;Mueller, Manfred James
背景：自愿睡眠限制是现代社会的一种生活方式，可能导致肥胖和糖尿病。该研究的目的是调查部分睡眠剥夺对能量平衡和胰岛素敏感性调节的影响。主题和方法：在一项对照干预中，14名健康女性（年龄23-38岁，BMI 20.0-36.6 kg/m2）在2个晚上睡眠>8小时/晚（TO）后，（7小时睡眠/夜，6小时睡眠/夜，6小时睡眠/夜和4小时睡眠/夜; T1）和2晚睡眠恢复后（>8小时睡眠/夜，T2）。评估静息和总能量消耗（REE，TEE），葡萄糖诱导产热（GIT），体力活动，能量摄入，葡萄糖耐量和内分泌参数。结果如下：在睡眠持续时间减少后，能量摄入（+20%）、体重（+0.4 kg）、瘦素/脂肪质量（+29%）、游离三碘甲状腺原氨酸（+19%）、游离甲状腺素（+10%）和GIT（+34%）显著增加（所有p < 0.05）。平均REE、体力活动、TEE、口服葡萄糖耐量和ghrelin水平在T1时保持不变。睡眠不足对GIT，fT 3和fT 4水平的影响与脂肪量呈负相关。结论：短期睡眠剥夺增加了女性的能量摄入并导致净体重增加。睡眠限制对能量消耗的影响需要在未来的研究中使用总能量消耗的参考方法来具体解决。
Background: Voluntary sleep restriction is a lifestyle feature of modern societies that may contribute to obesity and diabetes. The aim of the study was to investigate the impact of partial sleep deprivation on the regulation of energy balance and insulin sensitivity. Subjects and Methods: In a controlled intervention, 14 healthy women (age 23-38 years, BMI 20.0-36.6 kg/m(2)) were investigated after 2 nights of >8 h sleep/night (TO), after 4 nights of consecutively increasing sleep curtailment (7 h sleep/night, 6 h sleep/night, 6 h sleep/night and 4 h sleep/night; T1) and after 2 nights of sleep recovery (>8 h sleep/night, T2). Resting and total energy expenditure (REE, TEE), glucose-induced thermogenesis (GIT), physical activity, energy intake, glucose tolerance and endocrine parameters were assessed. Results: After a decrease in sleep duration, energy intake (+20%), body weight (+0.4 kg), leptin / fat mass (+29%), free triiodothyronine (+19%), free thyroxine (+10%) and GIT (+34%) significantly increased (all p < 0.05). Mean REE, physical activity, TEE, oral glucose tolerance, and ghrelin levels remained unchanged at T1. The effect of sleep loss on GIT, fT3 and fT4 levels was inversely related to fat mass. Conclusion: Short-term sleep deprivation increased energy intake and led to a net weight gain in women. The effect of sleep restriction on energy expenditure needs to be specifically addressed in future studies using reference methods for total energy expenditure.