Regulation and Immune Function of IL-27.
Regulation and Immune Function of IL-27.
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DOI：
10.1007/978-94-024-0921-5_9
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发表时间：
2016
影响因子：
--
通讯作者：
Qinghong Wang;Jianguo Liu
中科院分区：
文献类型：
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作者：
Qinghong Wang;Jianguo Liu
IL-27是一种多效性细胞因子，在生理和病理条件下具有多种免疫调节活性。IL-27增强Th1和CD8+T细胞的功能，促进Tfh和Tr1的发育，抑制Th2、Treg、Th9和Th17细胞的功能。IL-27还参与调节B细胞、NK细胞、dc细胞和巨噬细胞的免疫反应。IL-27的产生在转录和转录后水平受到严格调控。鉴于其在免疫调节中的广泛作用，IL-27已被认为与自身免疫性疾病和传染性疾病以及癌症的发病机制有关。本章综述了IL-27的生物学特性，包括IL-27产生的分子机制和潜在的细胞信号通路。本文还讨论了IL-27在自身免疫性疾病、感染性疾病和癌症的免疫应答中的调节作用。
IL-27 is a pleiotropic cytokine that has diverse immune regulatory activities under both physiological and pathological conditions. IL-27 enhances the functions of Th1 and CD8+T cells, promotes the development of Tfh and Tr1, and suppresses the functions of Th2, Treg, Th9, and Th17 cells. IL-27 is also involved in regulation of immune responses of B cells, NK, DCs, and macrophages. IL-27 production is strictly regulated at both transcriptional and posttranscriptional levels. Given its broad effects on immune regulation, IL-27 has been implicated in the pathogeneses of autoimmune and infectious diseases as well as cancers. In this chapter, the biological characters of IL-27 have been reviewed, including the molecular mechanisms of IL-27 production and the underlying cellular signaling pathway. The regulatory effects of IL-27 on immune responses in autoimmune disease, infectious disease, and cancer are also discussed.