Neuroimaging Auditory Hallucinations in Schizophrenia: From Neuroanatomy to Neurochemistry and Beyond
Neuroimaging Auditory Hallucinations in Schizophrenia: From Neuroanatomy to Neurochemistry and Beyond
复制标题
DOI：
10.1093/schbul/sbs066
复制
发表时间：
2012-06-01
影响因子：
6.6
通讯作者：
Hoffman, Ralph
中科院分区：
文献类型：
--
作者：
Allen, Paul;Modinos, Gemma;Hoffman, Ralph
尽管神经影像学研究已经进行了 20 多年，但目前还没有足够的证据来完全理解幻听 (AH) 的神经生物学基础。然而，对 AH 患者的影像学研究已取得一些进展，一致报告言语和语言、感觉和非感觉区域的结构和功能发生改变。本报告提供了 AH 神经影像学研究的最新情况，特别强调最近的解剖学、生理学和神经化学影像学研究。具体来说，我们提供（1）对精神分裂症和非精神分裂症语音听众的研究结果的回顾，（2）对干扰进展的关键问题的讨论，以及（3）对未来研究的实用建议。
Despite more than 2 decades of neuroimaging investigations, there is currently insufficient evidence to fully understand the neurobiological substrate of auditory hallucinations (AH). However, some progress has been made with imaging studies in patients with AH consistently reporting altered structure and function in speech and language, sensory, and nonsensory regions. This report provides an update of neuroimaging studies of AH with a particular emphasis on more recent anatomical, physiological, and neurochemical imaging studies. Specifically, we provide (1) a review of findings in schizophrenia and nonschizophrenia voice hearers, (2) a discussion regarding key issues that have interfered with progress, and (3) practical recommendations for future studies.