Central adrenergic control of vasopressin release.
Central adrenergic control of vasopressin release.
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中枢肾上腺素能控制加压素的释放。
DOI：
10.1159/000124480
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发表时间：
1986
影响因子：
4.1
通讯作者：
Crofton,JT
中科院分区：
文献类型：
--
作者：
Brooks,DP;Share,L;Crofton,JT
在清醒的大鼠中研究了中枢肾上腺素受体在控制加压素释放中的作用。脑室内注射去甲肾上腺素 (10 µg) 和 α-1 激动剂去氧肾上腺素 (50 µg) 会导致血浆加压素浓度和血压显着升高。 α-2 激动剂 BHT 933 (50 µg) 和 β 激动剂异丙肾上腺素 (10 µg) 均会导致血浆加压素浓度显着降低，而血压仅发生微小变化。 α-1 拮抗剂 Corynanthine (20 µg) 的中枢给药对血浆加压素浓度没有影响；然而，当给予α-2拮抗剂育亨宾（20微克）或β拮抗剂普萘洛尔（20微克）时，观察到血浆加压素水平增加。结论是，中枢去甲肾上腺素能途径可能在控制加压素释放中发挥重要作用，并且这种控制可能涉及α-1、α-2和β肾上腺素受体。
The role of central adrenergic receptors in the control of vasopressin release was studied in the conscious rat. Norepinephrine (10 µg) and the alpha-1 agonist, phenylephrine (50 µg), administered intracerebroventricularly resulted in significant increases in the plasma vasopressin concentration and blood pressure. The alpha-2 agonist, BHT 933 (50 µg) and the beta agonist, isoproterenol (10 µg) both caused a significant decrease in the plasma vasopressin concentration with only small changes in blood pressure. The central administration of the alpha-1 antagonist corynanthine (20 µg) had no effect on the plasma vasopressin concentration; however, increases in plasma vasopressin levels were observed when either the alpha-2 antagonist yohimbine (20 µg) or the beta antagonist propranolol (20 µg) were given. It is concluded that central noradrenergic pathways may play an important role in the control of vasopressin release and that this control may involve alpha-1, alpha-2 and beta adrenoreceptors.