Relationship between physiological response type (RA and SA) and vibrissal receptive field of neurons within the rat trigeminal ganglion
Relationship between physiological response type (RA and SA) and vibrissal receptive field of neurons within the rat trigeminal ganglion
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DOI：
10.1152/jn.00157.2005
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发表时间：
2006-05-01
影响因子：
2.5
通讯作者：
Moxon, KA
中科院分区：
文献类型：
--
作者：
Leiser, SC;Moxon, KA
三叉神经节（Vg）内的细胞编码的所有必要的信息，大鼠区分触觉刺激，但它是最少研究的组成部分，在啮齿动物三叉神经体感系统。例如，广泛的解剖学和电生理学研究表明，在该系统的更高水平，包括VPM丘脑和SI皮层，清晰的躯体定位组织，但这种保守的图式是否存在于Vg是未知的。此外，虽然最近有兴趣在Vg中的触须反应细胞的记录，这是令人惊讶的注意到，这些细胞的位置甚至没有明确划定。为了解决这个问题，我们记录了350个感觉反应Vg神经元在35个Long-Evans大鼠的细胞外。首先，我们确定了这些细胞的三维位置，并发现了比以前报道的更精细的细节。细胞支配背面部特征，甚至在胡须区域，更背比中线和腹侧功能。我们还显示了更多的细胞与尾侧比喙须感受野（RF），类似于VPM和SI中发现的。接下来，对于每个触须细胞，我们确定其响应类型分类为快速（RA）或缓慢（SA）适应。我们研究了触须RF和反应类型之间的关系，并证明了相似的比例RA和SA细胞响应任何晶须。这些结果表明，如果RA和SA细胞编码不同的功能的刺激，如前所述，然后在基本的生理水平上，每个胡须有类似的能力，编码这些功能。
Cells within the trigeminal ganglion (Vg) encode all the information necessary for the rat to differentiate tactile stimuli, yet it is the least-studied component in the rodent trigeminal somatosensory system. For example, extensive anatomical and electrophysiological investigations have shown clear somatotopic organization in the higher levels of this system, including VPM thalamus and SI cortex, yet whether this conserved schemata exists in the Vg is unknown. Moreover although there is recent interest in recording from vibrissae-responsive cells in the Vg, it is surprising to note that the locations of these cells have not even been clearly demarcated. To address this, we recorded extracellularly from 350 sensory-responsive Vg neurons in 35 Long-Evans rats. First, we determined three-dimensional locations of these cells and found a finer detail of somatotopy than previously reported. Cells innervating dorsal facial features, even within the whisker region, were more dorsal than midline and ventral features. We also show more cells with caudal than rostral whisker receptive fields (RF), similar to that found in VPM and SI. Next, for each vibrissal cell we determined its response type classified as either rapidly ( RA) or slowly ( SA) adapting. We examined the relationship between vibrissal RF and response type and demonstrate similar proportions of RA and SA cells responding to any whisker. These results suggest that if RA and SA cells encode distinct features of stimuli, as previously suggested, then at the basic physiological level each whisker has similar abilities to encode for such features.