Hypocapnia attenuates local skin thermal perception to innocuous warm and cool stimuli in normothermic resting humans
Hypocapnia attenuates local skin thermal perception to innocuous warm and cool stimuli in normothermic resting humans
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DOI：
10.1152/ajpregu.00126.2022
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发表时间：
2023-01-01
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影响因子：
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通讯作者：
Nishiyasu，Takeshi
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作者：
Fujimoto，Tomomi;Dobashi，Kohei;Nishiyasu，Takeshi
当一个人在日常生活中暴露在压力环境中时，一个常见的反应是过度换气。虽然应激诱导的过度换气的生理意义仍然不确定，但这种反应可能会减弱对应激诱导刺激的感知。本研究探讨了自愿过度通气和由此产生的低碳酸血症对局部皮肤热检测阈值在常温休息的人的影响。本文测定了15名青年人（3名女性）在三种呼吸状态下的局部皮肤热检测阈值：1）自主呼吸（对照试验），2）自主低碳酸血症过度通气（HH试验），3）自主正常碳酸血症过度通气（NH试验）。局部皮肤热检测阈值测量使用热刺激器包含一个珀尔帖元件，被连接到前臂和前额。探头的温度最初与皮肤温度平衡，然后以恒定速率（±0.1 °C/s）逐渐增加或降低，直到参与者感到温暖或凉爽。初始皮肤温度与参与者注意到温暖/凉爽的局部皮肤温度之间的差异被评估为局部皮肤温暖/凉爽检测阈值的指标。局部检测的温暖和凉爽的刺激之间没有显着差异的控制和NH试验，但它是钝化的HH试验相比，控制和NH试验，除了检测前臂上的温暖刺激。这些发现表明，过度换气引起的低碳酸血症，而不是过度换气本身，减弱了局部皮肤热感知，尽管在某些皮肤区域可能无法清楚地感知到对温暖刺激的反应的变化（例如，前臂）。
When one is exposed to a stressful situation in their daily life, a common response is hyperventilation. Although the physiological significance of stress-induced hyperventilation remains uncertain, this response may blunt perception of the stress-inducing stimulus. This study examined the effects of voluntary hyperventilation and resultant hypocapnia on the local skin thermal detection threshold in normothermic resting humans. Local skin thermal detection thresholds were measured in 15 young adults (three females) under three breathing conditions:1) spontaneous breathing (Control trial),2) voluntary hypocapnic hyperventilation (HH trial), and3) voluntary normocapnic hyperventilation (NH trial). Local skin thermal detection thresholds were measured using thermostimulators containing a Peltier element that were attached to the forearm and forehead. The temperature of the probe was initially equilibrated to the skin temperature, then gradually increased or decreased at a constant rate (±0.1 °C/s) until the participants felt warmth or coolness. The difference between the initial skin temperature and the local skin temperature at which the participant noticed warmth/coolness was assessed as an index of the local skin warm/cool detection threshold. Local detection of warm and cool stimuli did not differ between the Control and NH trials, but it was blunted in the HH trial as compared with the Control and NH trials, except for detection of warm stimuli on the forearm. These findings suggest that hyperventilation-induced hypocapnia, not hyperventilation per se, attenuates local skin thermal perception, though changes in responses to warm stimuli may not be clearly perceived at some skin areas (e.g., forearm).