APPLICATION OF ANGIOGENIC OLIGOSACCHARIDES OF HYALURONAN INCREASES BLOOD-VESSEL NUMBERS IN RAT SKIN
APPLICATION OF ANGIOGENIC OLIGOSACCHARIDES OF HYALURONAN INCREASES BLOOD-VESSEL NUMBERS IN RAT SKIN
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DOI：
10.1111/1523-1747.ep12396880
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发表时间：
1994-10-01
影响因子：
6.5
通讯作者：
LEDGER, P
中科院分区：
文献类型：
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作者：
SATTAR, A;ROONEY, P;LEDGER, P
将透明质酸的血管生成低聚糖涂于年轻成年雄性大鼠的背部，并对表皮基部下136 μ m深度内的血管数量进行评估。与对照组相比，应用透明质酸寡糖显著增加了11只治疗大鼠中6只的平均血管数量/毫米皮肤长度。将放射性标记的透明质酸寡糖应用于一只大鼠的皮肤，其渗透深度约为800 μ m，这表明表皮下的血管可能暴露于透明质酸。透明质酸曾被证明能刺激内皮细胞增殖；我们在这里证明，这些透明质酸寡糖也特异性地刺激内皮细胞迁移。透明质酸寡糖的这种作用可能在延缓衰老过程和放疗后观察到的血管缺乏和变性方面证明是有用的。
Angiogenic oligosaccharides of hyaluronan were applied to the backs of young, adult male rats and the number of blood vessels, within a depth of 136 mu m beneath the base of the epidermis, were evaluated. Application of hyaluronan oligosaccharides significantly increased the mean number of blood vessels/mm skin length in six of 11 treated rats when compared with controls. Application of radiolabeled hyaluronan oligosaccharides to skin of one rat demonstrated a penetration to a depth of approximately 800 mu m, suggesting that the blood vessels beneath the epidermis would be exposed to the hyaluronan. Hyaluronan has previously been shown to stimulate endothelial cell proliferation; we demonstrate here that these hyaluronan oligosaccharides also specifically stimulate endothelial cell migration. This action of hyaluronan oligosaccharides may prove useful in retarding blood vessel paucity and degeneration observed during the ageing process and following radiotherapy.