Immunomodulation by Mesenchymal Stromal Cells and Their Clinical Applications.
Immunomodulation by Mesenchymal Stromal Cells and Their Clinical Applications.
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DOI：
10.15436/2471-0598.17.022
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Rilo HLR
中科院分区：
文献类型：
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作者：
Cagliani J;Grande D;Molmenti EP;Miller EJ;Rilo HLR
间充质基质细胞 (MSC) 是多能祖细胞，可以从各种来源分离和扩增。 MSC 调节免疫细胞的功能，包括 T 和 B 淋巴细胞、树突状细胞和自然杀伤细胞。了解 MSC 与炎症微环境之间的相互作用将为揭示 MSC 介导的治疗效果所涉及的精确体内机制以及为这些细胞的临床使用设计更实用的方案提供关键信息。在这篇综述中，我们描述了目前对 MSC 独特生物学特性、对免疫活性细胞的免疫抑制作用以及可溶性因子的旁分泌作用的了解。总结了 MSC 参与治疗自身免疫性疾病和其他疾病的临床前和临床研究。我们还讨论了它们当前的使用挑战及其在细胞疗法中的潜在作用。
Mesenchymal stromal cells (MSCs) are multipotent progenitor cells that can be isolated and expanded from various sources. MSCs modulate the function of immune cells, including T and B lymphocytes, dendritic cells, and natural killer cells. An understanding of the interaction between MSCs and the inflammatory microenvironment will provide critical information in revealing the precise in vivo mechanisms involved in MSCs-mediated therapeutic effects, and for designing more practical protocols for the clinical use of these cells. In this review we describe the current knowledge of the unique biological properties of MSCs, the immunosuppressive effects on immune-competent cells and the paracrine role of soluble factors. A summary of the participation of MSCs in preclinical and clinical studies in treating autoimmune diseases and other diseases is described. We also discuss the current challenges of their use and their potential roles in cell therapies.