Estrogen Receptor Alpha Distribution and Expression in the Social Neural Network of Monogamous and Polygynous Peromyscus.
Estrogen Receptor Alpha Distribution and Expression in the Social Neural Network of Monogamous and Polygynous Peromyscus.
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DOI：
10.1371/journal.pone.0150373
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Cushing BS
中科院分区：
文献类型：
--
作者：
Cushing BS
在田鼠和侏儒仓鼠中，终纹床核（BST）和内侧杏仁核（MeA）中的低水平雌激素受体α（ERα）在雄性社会一夫一妻制的表达中起着关键作用，其特征是高水平的联系和低水平的攻击。与此相反，一夫一妻制的Peromyscus雄性动物表现出高水平的侵略性和亲和行为，具有高水平的睾酮和芳香化酶活性。提示在鹿鼠中ERα的表达与雄性高水平的亲社会行为和攻击性呈正相关。比较了两种一夫一妻制物种（P.californicus和P.polionotus）和两种一夫多妻制物种（P.leucopus和P.maniculatus）的社会神经网络（包括后内侧BST、MeA后背、内侧视前区（MPOA）、下丘脑腹内侧（VMH）和弓状核）中ERα的表达。结果支持了这一预测，即雄性灰背飞虱和加利福尼亚飞虱的雌激素受体α在BST中的表达水平高于其一雌多雌的对应个体，雌激素受体α在一雌多雌的物种中的表达水平显著高于雄性，在白背飞虱的MeA中的表达水平显著高于雌性。大鼠、小鼠和田鼠的穿孔鼠ERα表达也不同，因为MPOA和VMH的ERα均不具有性二型性。结果支持了这一假设，即高水平的ERα与Peromycus的一夫一妻制有关，ERα的差异表达发生在大脑的相同区域，无论高或低表达与社会一夫一妻制有关。还讨论了调节这种差异关系的可能机制。
In microtine and dwarf hamsters low levels of estrogen receptor alpha (ERα) in the bed nucleus of the stria terminalis (BST) and medial amygdala (MeA) play a critical role in the expression of social monogamy in males, which is characterized by high levels of affiliation and low levels of aggression. In contrast, monogamous Peromyscus males display high levels of aggression and affiliative behavior with high levels of testosterone and aromatase activity. Suggesting the hypothesis that in Peromyscus ERα expression will be positively correlated with high levels of male prosocial behavior and aggression. ERα expression was compared within the social neural network, including the posterior medial BST, MeA posterodorsal, medial preoptic area (MPOA), ventromedial hypothalamus (VMH), and arcuate nucleus in two monogamous species, P. californicus and P. polionotus, and two polygynous species, P. leucopus and P. maniculatus. The results supported the prediction, with male P. polionotus and P. californicus expressing higher levels of ERα in the BST than their polygynous counter parts, and ERα expression was sexually dimorphic in the polygynous species, with females expressing significantly more than males in the BST in both polygynous species and in the MeA in P. leucopus. Peromyscus ERα expression also differed from rats, mice and microtines as in neither the MPOA nor the VMH was ERα sexually dimorphic. The results supported the hypothesis that higher levels of ERα are associated with monogamy in Peromyscus and that differential expression of ERα occurs in the same regions of the brains regardless of whether high or low expression is associated with social monogamy. Also discussed are possible mechanisms regulating this differential relationship.