Science review: searching for gene candidates in acute lung injury.
Science review: searching for gene candidates in acute lung injury.
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科学评论：寻找急性肺损伤中的基因候选者。
DOI：
10.1186/cc2901
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发表时间：
2004-12
期刊：
影响因子：
15.1
通讯作者：
Garcia, JGN
中科院分区：
文献类型：
--
作者：
Grigoryev, DN;Finigan, JH;Hassoun, P;Garcia, JGN
急性肺损伤（ALI）是一种复杂和毁灭性的疾病，通常在败血症的情况下发生，年死亡率为30-50%。尽管ALI的遗传基础尚未完全确定，但越来越多的证据表明，遗传易感性有助于疾病的易感性和严重程度。然而，在确定这些遗传因素的确切性质方面存在重大困难，包括大的表型差异、不完全外显率、复杂的基因-环境相互作用以及位点异质性的巨大潜力。我们利用候选基因方法和同源基因数据库来提供相关的基因本体，并深入了解ALI的遗传基础。我们使用Medline检索精选的英文文献中的基础和临床研究，以及由HopGene国家卫生研究院赞助的基因组应用项目赞助的研究。在ALI动物模型（大鼠、小鼠、犬）以及人类中进行了广泛的基因表达谱研究，以确定潜在的候选基因。我们确定了许多ALI的候选基因，其中凝血和炎症基因本体是最具代表性的。候选基因方法结合广泛的基因谱分析和新的生物信息学方法是鉴定ALI中涉及的基因的有价值的方法。
Acute lung injury (ALI) is a complex and devastating illness, often occurring within the setting of sepsis, and carries an annual mortality rate of 30–50%. Although the genetic basis of ALI has not been fully established, an increasing body of evidence suggests that genetic predisposition contributes to disease susceptibility and severity. Significant difficulty exists, however, in defining the exact nature of these genetic factors, including large phenotypic variance, incomplete penetrance, complex gene–environment interactions, and strong potential for locus heterogeneity. We utilized the candidate gene approach and an ortholog gene database to provide relevant gene ontologies and insights into the genetic basis of ALI. We employed a Medline search of selected basic and clinical studies in the English literature and studies sponsored by the HopGene National Institutes of Health sponsored Program in Genomic Applications. Extensive gene expression profiling studies in animal models of ALI (rat, murine, canine), as well as in humans, were performed to identify potential candidate genes . We identified a number of candidate genes for ALI, with blood coagulation and inflammation gene ontologies being the most highly represented. The candidate gene approach coupled with extensive gene profiling and novel bioinformatics approaches is a valuable way to identify genes that are involved in ALI.
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影响因子：
3.7
作者：
Cover, PO;Baanah-Jones, F;Buckingham, JC
通讯作者：
Buckingham, JC
影响因子：
3.6
作者：
Diehl, S;Rincón, M
通讯作者：
Rincón, M
DOI：
10.1152/ajplung.2000.279.3.l592
发表时间：
2000-09-01
影响因子：
4.9
作者：
Dixon, AE;Mandac, JB;Clark, JG
通讯作者：
Clark, JG
影响因子：
6.7
作者：
Fernando, LP;Natesan, S;Kaplan, AP
通讯作者：
Kaplan, AP
影响因子：
4.8
作者：
He, YC;Crouch, E
通讯作者：
Crouch, E