HLA-C*12:02 is strongly associated with Xuesaitong-induced cutaneous adverse drug reactions
HLA-C*12:02 is strongly associated with Xuesaitong-induced cutaneous adverse drug reactions
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HLA-C12:02与血塞通引起的皮肤药物不良反应密切相关
DOI：
10.1038/s41397-018-0051-3
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发表时间：
2019-06-01
影响因子：
2.8
通讯作者：
Xing, Qinghe
中科院分区：
文献类型：
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作者：
Yan, Sijia;Xiong, Hao;Xing, Qinghe
血塞通（XST）主要用于治疗心脑血管疾病，有时会引起皮肤药物不良反应（cADR），其致病机制或危险因素尚不清楚。我们的目的是验证中国汉族人群中人类白细胞抗原 (HLA) 等位基因是否与 XST 相关 cADR 相关。我们进行了一项关联研究，包括 12 名 XST 诱导的 cADR 受试者、283 名对照者和 28 名 XST 耐受受试者。 12名XST诱导的cADR患者中有5名携带HLA-C*12:02，所有患者均通过静脉滴注接受XST。与对照人群相比，HLA-C*12:02 的携带频率显着较高（Pc = 4.4 x 10(-4)，比值比（OR） = 21.75，95% CI = 5.78-81.88）。与XST耐受组相比，静脉滴注接受XST的患者cADRs OR较高（Pc = 0.011，OR = 27.00，95% CI = 2.58-282.98）。结果表明，HLA-C*12:02 是汉族人群中 XST 诱导的 cADR 的潜在预测标志物，特别是当 XST 通过静脉滴注给药时。
Xuesaitong (XST) is mainly used to treat cardiovascular and cerebrovascular diseases, sometimes causing cutaneous adverse drug reactions (cADRs) with unknown mechanisms of pathogenicity or risk factors. We aimed to verify whether human leukocyte antigen (HLA) alleles are associated with XST-related cADRs in Han Chinese population. We carried out an association study including 12 subjects with XST-induced cADRs, 283 controls, and 28 XST-tolerant subjects. Five out of 12 patients with XST-induced cADRs carried HLA-C*12:02, and all of them received XST via intravenous drip. The carrier frequency of HLA-C*12:02 was significantly high compare to that of the control population (Pc = 4.4 x 10(-4), odds ratio (OR) = 21.75, 95% CI = 5.78-81.88). Compared with that of the XST-tolerant group, the patients who received XST through intravenous drip presented a higher OR of cADRs (Pc = 0.011, OR = 27.00, 95% CI = 2.58-282.98). The results suggest that HLA-C*12:02 is a potentially predictive marker of XST-induced cADRs in Han Chinese, especially when XST is administered via intravenous drip.