Hypophosphatemia as a Predictor of Clinical Outcomes in Acute Pancreatitis: A Retrospective Study.
Hypophosphatemia as a Predictor of Clinical Outcomes in Acute Pancreatitis: A Retrospective Study.
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低磷血症作为急性胰腺炎临床结果的预测因子：一项回顾性研究。
DOI：
10.1097/mpa.0000000000002265
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发表时间：
2024
期刊：
影响因子：
2.9
通讯作者：
Liddle,RodgerA
中科院分区：
文献类型：
--
作者：
Lee,JoshuaP;Darlington,Kimberly;Henson,JacquelineB;Kothari,Darshan;Niedzwiecki,Donna;Farooq,Ahmad;Liddle,RodgerA
磷酸盐对损伤后的细胞修复至关重要，并且可能对急性胰腺炎（AP）后的恢复很重要。本研究旨在评估低磷血症与AP严重程度之间的相关性。方法确定2014-2018年期间收治的AP患者，并对其记录进行回顾性分析。胰腺炎严重程度采用改良亚特兰大标准定义。低磷酸盐血症定义为磷酸盐< 2 mg/dL，并在三个时间点进行评估：一天内，两天内，入院期间的任何时间。发生严重AP的患者的比例进行了比较，患者与无低磷血症。ResultsOf 312例患者中，30.1%（n= 94）发展严重AP。低磷血症总体发生率为25.0%，1天内发生率为19.7%，2天内发生率为20.0%。高比例的低磷血症患者发生重度AP（总体：47.4% vs. 24.4%，P< 0.001; 1天：47.4% vs. 23.9%，P= 0.004; 2天：42.9% vs. 24.5%，P= 0.01）。低磷血症1天内的患者也更有可能有ICU入院（P< 0.001）和更长的住院时间（P< 0.001）。结论AP入院期间的早期低磷血症与AP严重程度增加，ICU入院和更长的住院时间相关。
ObjectivePhosphate is crucial for cellular repair after injury and may be important in recovery following acute pancreatitis (AP). This study aimed to evaluate the association between hypophosphatemia and severity of AP.MethodsPatients admitted with AP between 2014–2018 were identified and their records were retrospectively reviewed. Pancreatitis severity was defined using the modified Atlanta Criteria. Hypophosphatemia was defined as phosphate< 2 mg/dL and was assessed at three time points: within one day, within two days, at any time during admission. The proportion of patients who developed severe AP was compared between patients with and without hypophosphatemia.ResultsOf 312 patients, 30.1%(n= 94) developed severe AP. Hypophosphatemia occurred in 25.0% overall, within one day in 19.7%, and within two days in 20.0%. A higher proportion of patients with hypophosphatemia developed severe AP (overall: 47.4% vs. 24.4%, P< 0.001; one day: 47.4% vs. 23.9%, P= 0.004; two days: 42.9% vs. 24.5%, P= 0.01). Patients with hypophosphatemia within one day were also more likely to have ICU admission (P< 0.001) and longer length of stay (P< 0.001).ConclusionsEarly hypophosphatemia during an admission for AP was associated with increased AP severity, ICU admission, and longer length of stay.