Prognostic significance of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 in primary breast cancer.
Prognostic significance of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 in primary breast cancer.
复制标题
DOI：
10.1038/bjc.1998.154
复制
发表时间：
1998-03
影响因子：
8.8
通讯作者：
Rose, C
中科院分区：
文献类型：
--
作者：
Knoop, A;Andreasen, P A;Andersen, J A;Hansen, S;Laenkholm, A V;Simonsen, A C;Andersen, J;Overgaard, J;Rose, C
UPA介导的纤溶酶原激活途径是肿瘤转移的中心环节。目前尚不清楚uPA和PAI-1是否与局部复发、转移扩散或两者都有关。我们对429例乳腺癌患者进行了回顾性研究，中位随访时间为5.1年。用酶联免疫吸附试验分析了肿瘤提取物中uPA和PAI-1的水平。以uPA和PAI-1为界点的中位数分别为4.5和11.1 ng mg(-1)蛋白。UPA和PAI-1水平与肿瘤大小、间变程度、激素受体状态和阳性结节数有关。尿激酶型纤溶酶原激活物或纤溶酶原激活物-1含量高的患者复发和死亡的风险增加。我们证明了PAI-1预测远处转移的独立能力(相对危险度1.7，置信限1.22和2.46)，并且uPA和PAI-1都没有提供任何关于局部复发的信息。
The uPA-mediated pathway of plasminogen activation is central to cancer metastasis. Whether uPA and PAI-1 are related to local recurrence, metastatic spread or both is not clear. We present a retrospective study of 429 primary breast cancer patients with a median follow-up of 5.1 years, in which the levels of uPA and PAI-1 in tumour extracts were analysed by means of an enzyme-linked immunosorbent assay. The median values of uPA and PAI-1, which were used as cut-off points, were 4.5 and 11.1 ng mg(-1) protein respectively. The levels of uPA and PAI-1 were correlated with tumour size, degree of anaplasia, steroid receptor status and number of positive nodes. Patients with high content of either uPA or PAI-1 had increased risk of relapse and death. We demonstrated an independent ability of PAI-1 to predict distant metastasis (relative risk 1.7, confidence limits 1.22 and 2.46) and that neither uPA nor PAI-1 provided any information regarding local recurrence.