Cellular networks underlying human spatial navigation
Cellular networks underlying human spatial navigation
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DOI：
10.1038/nature01964
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发表时间：
2003-09-11
期刊：
影响因子：
64.8
通讯作者：
Fried, I
中科院分区：
文献类型：
--
作者：
Ekstrom, AD;Kahana, MJ;Fried, I
啮齿动物海马体的位置细胞是哺乳动物中神经元活动与复杂行为之间相关性的最显著例子之一（1,2）。当动物穿过其周围环境的特定区域时，这些细胞的放电频率会增加，从而提供一种依赖于环境的地图（3 - 5）。神经影像学研究表明海马体和海马旁回区域参与人类的导航（6 - 8）。然而，这些区域也对视觉刺激有选择性反应（9 - 13）。因此，目前尚不清楚啮齿动物的位置编码在人类中是否有同源物，或者人类的导航是否由一种不同的、基于视觉的神经机制所驱动。我们在受试者探索和在一个虚拟城镇中导航时，直接记录了人类内侧颞叶和额叶的317个神经元的活动。在此，我们提供了基于在特定空间位置有反应的细胞以及对地标的视觉有反应的细胞的人类空间导航神经编码的证据。前者主要存在于海马体中，后者存在于海马旁回区域。整个额叶和颞叶的细胞对受试者的导航目标以及位置、目标和视觉的组合有反应。
Place cells of the rodent hippocampus constitute one of the most striking examples of a correlation between neuronal activity and complex behaviour in mammals(1,2). These cells increase their firing rates when the animal traverses specific regions of its surroundings, providing a context-dependent map of the environment(3-5). Neuroimaging studies implicate the hippocampus and the parahippocampal region in human navigation(6-8). However, these regions also respond selectively to visual stimuli(9-13). It thus remains unclear whether rodent place coding has a homologue in humans or whether human navigation is driven by a different, visually based neural mechanism. We directly recorded from 317 neurons in the human medial temporal and frontal lobes while subjects explored and navigated a virtual town. Here we present evidence for a neural code of human spatial navigation based on cells that respond at specific spatial locations and cells that respond to views of landmarks. The former are present primarily in the hippocampus, and the latter in the parahippocampal region. Cells throughout the frontal and temporal lobes responded to the subjects' navigational goals and to conjunctions of place, goal and view.