Resistance levels and rpoB gene mutations among in vitro-selected rifampin-resistant Mycobacterium tuberculosis mutants
Resistance levels and rpoB gene mutations among in vitro-selected rifampin-resistant Mycobacterium tuberculosis mutants
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DOI：
10.1128/aac.00303-06
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发表时间：
2006-08-01
影响因子：
4.9
通讯作者：
Hoffner, Sven
中科院分区：
文献类型：
--
作者：
Huitric, Emma;Werngren, Jim;Hoffner, Sven
本文对189株结核分枝杆菌利福平耐药突变株的分布及耐药水平进行了测定。除了更高数量的密码子522点突变和大的缺失外，还观察到与临床分离株报告的突变相似的突变扩散。大多数突变与高水平耐药相关;较低水平或MIC < 16 mg/L与密码子522突变相关。在两个北京突变体中检测到多个突变。
The distribution and resistance levels of 189 in vitro-selected rifampin-resistant Mycobacterium tuberculosis mutants of Beijing and other genotypes were determined. Apart from a higher amount of codon 522 point mutations and large deletions, a spread of mutations similar to that reported for clinical isolates was seen. Most mutations were correlated with high-level resistance; a lower level, or a MIC of < 16 mg/liter, was associated with codon 522 mutations. Multiple mutations were detected in two Beijing mutants.