Epidemiology of gastroesophageal reflux disease in Tehran, Iran
Epidemiology of gastroesophageal reflux disease in Tehran, Iran
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DOI：
10.1111/j.1440-1746.2006.04616.x
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发表时间：
2007-09-01
影响因子：
4.1
通讯作者：
Mashayekh, Ameneh
中科院分区：
文献类型：
--
作者：
Ehsani, Mohammad J.;Maleki, Iradj;Mashayekh, Ameneh
背景与目的：流行病学研究表明，胃食管反流病在西方国家的患病率有所上升；然而，缺乏有关其在伊朗流行程度的信息。本研究的目的是测量1999年德黑兰人口代表性样本中胃食管反流病的患病率。方法：在横断面研究中，以胃食管反流病患病率为20%的概率和3%的误差为基础，采用分层随机化方法，选择男女比例为1:1的700人。他们被平均分为七个年龄组。胃灼热和反酸被认为是胃食管反流病最常见的症状。确定了胃灼热的严重程度和频率以及个人习惯在这种症状出现中的作用。测量样本中胃食管反流病的患病率，并估计其在社会中的实际患病率。结果：700人中，男性350人，女性350人。278人（39.7%）出现胃食管反流病的主要症状。吸烟者胃食管反流病的患病率是非吸烟者的两倍。结论：胃食管反流病在西方国家是一个严重且未解决的问题，其发病率的上升与食管远端腺癌发病率的上升相关。胃食管反流病的患病率在伊朗似乎也在增加；因此，建议对该病给予高度重视。
Background and Aim: Epidemiological studies have indicated an increase in the prevalence of gastroesophageal reflux disease in Western countries; however, there is a lack of information about its prevalence in Iran. The aim of this study was to measure gastroesophageal reflux disease prevalence in a representative sample of the Tehran population in 1999.Methods: In a cross-sectional study, 700 people, with a male : female ratio of 1:1, were selected by stratified randomization based on the probability of 20% prevalence of gastroesophageal reflux disease and 3% error. They were divided equally into seven age groups. Heartburn and acid regurgitation were considered as the most common symptoms of gastroesophageal reflux disease. The severity and frequency of heartburn and the role of personal habits in the appearance of this symptom were determined. The prevalence of gastroesophageal reflux disease in samples was measured, and its actual prevalence in society was estimated.Results: Of 700 people, 350 were male and 350 were female. The major symptoms of gastroesophageal reflux disease were observed in 278 (39.7%) people. The prevalence of gastroesophageal reflux disease of smokers was twice that of non-smokers.Conclusions: Gastroesophageal reflux disease is a serious and unresolved problem in Western countries, and its increasing prevalence correlates with an increasing prevalence of adenocarcinoma of distal esophagus. The prevalence of gastroesophageal reflux disease appears to be increasing in Iran also; therefore, it is recommended that major attention be paid to this disease.