Is there more than one proctitis syndrome? A revisitation using data from the TROG 96.01 trial
Is there more than one proctitis syndrome? A revisitation using data from the TROG 96.01 trial
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DOI：
10.1016/j.radonc.2008.09.019
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发表时间：
2009-03-01
影响因子：
5.7
通讯作者：
Denham, James W.
中科院分区：
文献类型：
--
作者：
Capp, Anne;Inostroza-Ponta, Mario;Denham, James W.
目的：我们试图分类纵向辐射诱导的直肠毒性数据从男性参加随机对照试验局部晚期prostate cancel.Materials和方法：数据从自我评估问卷的直肠症状和临床医生记录的补救措施，收集在TROG 96.01试验。在这项试验中，志愿者被随机分配接受放射治疗，伴或不伴新辅助雄激素剥夺。症状强度的纵向变化的特点是通过患病率数据来实现的。一个集成的可视化和聚类方法的基础上模因算法被用来定义发生在辐射前，期间和之后的症状集群的组成。效用的CTC分级系统作为一种手段，确定具体的损伤配置文件进行了评估，使用一致性analysis.Results七个明确的集群直肠症状治疗前，25被认为是立即辐射后，7年1，2和3辐射后。在所有时间点，CTC分级与直肠“痛苦”和“问题”的程度不一致。一致性没有提高，增加紧迫性的CTC scale.Conclusions：CTC规模有严重的缺点。一个强大的新技术，非层次聚类可能有助于直肠毒性数据的基因组分析研究和详细的病理生理研究的分类。(C)2008爱思唯尔爱尔兰有限公司保留所有权利。放射治疗和肿瘤学90（2009）400-407
Purpose: We sought to categorize longitudinal radiation-induced rectal toxicity data obtained from men participating in a randomised controlled trial for locally advanced prostate cancel.Materials and methods: Data from self-assessed questionnaires of rectal symptoms and clinician recorded remedial interventions were collected during the TROG 96.01 trial. In this trial, Volunteers were randomised to radiation with or without neoadjuvant androgen deprivation. Characterization of longitudinal variations in symptom intensity was achieved using prevalence data. An integrated visualization and clustering approach based on memetic algorithms was used to define the compositions of symptom clusters occurring before, during and after radiation. The utility Of the CTC grading system as a means of identifying specific injury profiles was evaluated using concordance analyses.Results Seven well-defined Clusters OF rectal symptoms were present prior to treatment, 25 were seen immediately following radiation and 7 at years 1, 2 and 3 following radiation. CTC grading did not concord with degree of rectal 'distress' and 'problems' at all time points. Concordance was not improved by adding urgency to the CTC scale.Conclusions: The CTC scale has serious shortcomings. A powerful new technique for non-hierarchical Clustering may contribute to the categorization of rectal toxicity data for genomic profiling Studies and detailed patho-physiological studies. (C) 2008 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 90 (2009) 400-407