SEROTONIN SELECTIVELY INHIBITS GROWTH CONE MOTILITY AND SYNAPTOGENESIS OF SPECIFIC IDENTIFIED NEURONS
SEROTONIN SELECTIVELY INHIBITS GROWTH CONE MOTILITY AND SYNAPTOGENESIS OF SPECIFIC IDENTIFIED NEURONS
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DOI：
10.1126/science.6093252
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发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
KATER, SB
中科院分区：
文献类型：
--
作者：
HAYDON, PG;MCCOBB, DP;KATER, SB
神经递质5-羟色胺抑制了[Helisoma]特定识别神经元的生长锥体的运动活动，而其他识别的神经元则不受影响。因此，受影响的神经元无法形成电突触，而其他生长未受影响的神经元仍然可以相互连接。显然，神经递质除了在神经传递中发挥经典作用外，还可以在调节神经元结构和连接方面发挥重要作用。
The motile activity of growth cones of specific identified neurons [from Helisoma] was inhibited by the neurotransmitter serotonin, although other identified neurons were unaffected. As a consequence, affected neurons were unable to form electrical synapses, whereas other neurons whose growth is unaffected can still interconnect. Neurotransmitters evidently can play a prominent role in regulating neuronal architecture and connectivity in addition to their classical role in neurotransmission.